(R)-3-(3-甲基丁酰)-4-苄基-2-恶唑烷酮合成路线 (共 23 条)
反应条件
1: 76 percent / LiHMDS / tetrahydrofuran
2: 81 percent / LiOH; H2O2
3: 95 percent / LAH / tetrahydrofuran
4: 97 percent / PPh3; NBS / CH2Cl2
5: 68 percent / n-BuLi
6: HCl / acetonitrile
7: Et3N
8: NaBH4 / ethanol
9: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2
10: Mg
11: 23 percent / H2 / Pd(OH)2/C
12: 38 percent / TPAP; NMMO
13: 65 percent / 2-hydroxypyridine; Et3N
View Scheme
参考文献
CarboDesign LLC
Patent: US2011/137047 A1, 2011 ;
反应条件
1: 76 percent / LiHMDS / tetrahydrofuran
2: 81 percent / LiOH; H2O2
View Scheme
参考文献
MYLAN LABORATORIES LIMITED; RAMA, Shankar; VADALI, Lakshmana Rao; MANUKONDA, Seshadri rao; POTLA, Venkata Srinivas Rao; VADLAMUDI, Mohana Vamsi Krishna; DASARI, Srinivasa Rao
Patent: WO2013/171767 A1, 2013 ;
反应条件
1: 76 percent / LiHMDS / tetrahydrofuran
2: 81 percent / LiOH; H2O2
3: 95 percent / LAH / tetrahydrofuran
4: 97 percent / PPh3; NBS / CH2Cl2
5: 68 percent / n-BuLi
6: HCl / acetonitrile
7: Et3N
8: NaBH4 / ethanol
9: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2
10: Mg
11: 23 percent / H2 / Pd(OH)2/C
12: 38 percent / TPAP; NMMO
View Scheme
参考文献
CarboDesign LLC
Patent: US2011/137047 A1, 2011 ;