1-苄基-3-氨基吡咯烷-3-甲酸合成路线 （共 8 条）
反应条件
hydrogenchloride in chloroform; water 24 h; Reflux;
参考文献
WO2011/91548 A1, ;
Page/Page column 8-9 ;
反应条件
sodium hydroxide; hydrogen bromide in ethanol
反应条件
hydrogenchloride; hydrogen bromide; acetic acid 96 h; Heating;
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575
反应条件
1: 93 percent / HCl / 2 h / Heating 2: 98 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 3 h / Heating 3: 82 percent / CH2Cl2 / 2 h / 0 °C View Scheme
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575
反应条件
1: 93 percent / HCl / 2 h / Heating 2: 98 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 3 h / Heating View Scheme
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575
反应条件
1: 93 percent / HCl / 2 h / Heating 2: 98 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 3 h / Heating 3: 82 percent / CH2Cl2 / 2 h / 0 °C 4: H2 / 5percent Pd/C / ethanol / 3.5 h / 50 °C View Scheme
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575
反应条件
hydrogen; 5 Pd(II)/C(eggshell) in methanol; water
P=3800.26 Torr; 24 h;
参考文献
UNILEVER PLC; UNILEVER N.V.; HINDUSTAN UNILEVER LIMITED; CHANG, Xiaowei; KHOSHDEL, Ezat; PENG, Weimin; WANG, Jinfang; YAO, Yinfang
Patent: WO2011/91548 A1, 2011 ;
Location in patent: Page/Page column 9 ;
