反应条件
1: 98 percent / 4-dimethylaminopyridine / acetonitrile / 67 h / Ambient temperature
2: 1.) OsO4, pyridine, 2.) sodium hydrogen sulfite / 1.) RT, 3.5 h, 2.) water, RT, 2.5 h
3: 76 percent / NaIO4 / methanol; H2O / 0.08 h / Ambient temperature
4: 100 percent / K2CO3 / dimethylformamide / 2 h / 40 °C
5: 86 percent / TFA / CH2Cl2 / 0.17 h / Ambient temperature
6: H2 / 10percent Pd/C / acetic acid / 760 Torr / Ambient temperature
View Scheme
参考文献
Ishii; Ishikawa; Ohta; Suzuki; Harayama
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 8 p. 1993 - 1996