1-Boc-2-吡咯烷甲酸甲酯合成路线 （共 15 条）
反应条件
Candida antarctica lipase in phosphate buffer T=30°C; pH=6.8; 25 h;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 10 p. 1323 - 1333
反应条件
ammonia in methanol; water 72 h;
参考文献
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Patent: WO2009/146112 A1, 2009 ;
Location in patent: Page/Page column 40 ;
WO 2009/146112 A1
反应条件
1: pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester With lithium diisopropyl amide in tetrahydrofuran; n-heptane T=-78°C; 3 h; 2: methyl iodide in tetrahydrofuran; n-heptane T=0°C; 2.5 h;
参考文献
SUNOVION PHARMACEUTICALS INC.; HARDY, Larry, Wendell; HEFFERNAN, Michele, L., R.; WU, Frank, Xinhe; SPEAR, Kerry, L.; SARASWAT, Lakshmi, D.
Patent: WO2011/75699 A2, 2011 ;
Location in patent: Page/Page column 177 ;
WO 2011/075699 A1
反应条件
Candida antarctica lipase in phosphate buffer T=30°C; pH=6.8; 25 h;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 10 p. 1323 - 1333
反应条件
1.1: dichloromethane / 4 h / 20 °C / Cooling with ice
2.1: potassium carbonate / acetonitrile / 0.25 h / 0 °C
2.2: 16 h / Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Cooling with ice
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参考文献
ENDO PHARMACEUTICALS INC.; GUPTA, Sandeep; PRIESTLEY, Tony; LAPING, Nicholas, James
Patent: WO2014/28675 A1, 2014 ;
