2-甲氧基-5-(三氟甲氧基)苯甲醛合成路线 （共 7 条）
反应条件
sodium hydroxide; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; trifluoroacetic acid in dichloromethane; water
参考文献
Pfizer Inc.
Patent: US5294744 A1, 1994 ;
反应条件
1: 2-hydroxy-5-trifluoromethoxy-benzaldehyde With potassium carbonate in DMF (N,N-dimethyl-formamide) 0.5 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide)
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1460062 A1, 2004 ;
Location in patent: Page 70 ;
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in 1,4-dioxane; water T=80°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/821 A1, 2005 ;
Location in patent: Page 49 ;
WO 2005/000821 A1
反应条件
sulfuric acid; trifluoroacetic acid
反应条件
sodium tetrahydroborate in methanol T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/821 A1, 2005 ;
Location in patent: Page 49 ;
WO 2005/000821 A1
反应条件
boron tribromide in dichloromethane T=-20 - 0°C; 2 h; Inert atmosphere;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; HICKEN, Erik James; HUNT, Kevin W.; RODRIGUEZ, Martha E.; TANG, Tony P.; SIU, Michael
Patent: WO2013/148851 A1, 2013 ;
Location in patent: Paragraph 00244 ;
反应条件
hydrogenchloride; sodium hydroxide; acetic acid in hexane; water; tert-butyl alcohol
参考文献
Hoechst Marion Roussel, Inc.
Patent: US5932571 A1, 1999 ;
US 5932571 A
