3,4-二氟苯-1-磺酰氯合成路线 （共 4 条）
反应条件
chlorosulfonic acid T=0°C; 4 h;
参考文献
Pal, Manojit; Madan, Manjula; Padakanti, Srinivas; Pattabiraman, Vijaya R.; Kalleda, Srinivas; Vanguri, Akhila; Mullangi, Ramesh; Mamidi, N. V. S. Rao; Casturi, Seshagiri R.; Malde, Alpeshkumar; Gopalakrishnan; Yeleswarapu, Koteswar R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 19 p. 3975 - 3984
反应条件
hydrogenchloride; triphenylphosphine in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide
参考文献
AstraZeneca AB
Patent: US6498275 B1, 2002 ;
US 6498275 B1
反应条件
ammonia in dichloromethane T=-30°C; 0.666667 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/75152 A1, 2008 ;
Location in patent: Page/Page column 33; 34 ;
反应条件
1: 44 percent / aq. NH3 / dioxane / 6 h / 0 °C
2: 81 percent / NH2NH2 / acetonitrile / 6 h / Heating
View Scheme
参考文献
Pal, Manojit; Madan, Manjula; Padakanti, Srinivas; Pattabiraman, Vijaya R.; Kalleda, Srinivas; Vanguri, Akhila; Mullangi, Ramesh; Mamidi, N. V. S. Rao; Casturi, Seshagiri R.; Malde, Alpeshkumar; Gopalakrishnan; Yeleswarapu, Koteswar R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 19 p. 3975 - 3984
