1: 2-mercapto-4,6-dihydroxy-pyrimidine With sodium hydroxide in water 0.666667 h; 2: 1-iodo-propane in 1-methyl-pyrrolidin-2-one; water T=20°C; 22 h; 3: With hydrogenchloride in 1-methyl-pyrrolidin-2-one; water pH=2.5 - 6.5; 1 h;

1: in methanol; water T=25 - 30°C; 0.25 h; 2: With sodium hydroxide in methanol; water T=25 - 30°C; 3: With hydrogenchloride in methanol; water pH=< 2; 1 h;

hydrogenchloride; sodium hydroxide in water

1.1: nitric acid / 2 h / 20 °C 1.2: 0.5 h / 0 °C 2.1: N,N-diethylaniline; trichlorophosphate / 3 h / Reflux 3.1: tetrahydrofuran / 2 h / 0 - 10 °C 4.1: acetic acid; iron / ethanol; water / 0.33 h / 60 °C 5.1: sodium nitrite; acetic acid / toluene; water / 0.5 h / 20 °C 5.2: pH 8 - 9 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C 7.1: hydrogenchloride / water; methanol / 3 h / 20 °C 7.2: pH 8 - 9 View Scheme

1.1: nitric acid / 2 h / 20 °C 1.2: 0.5 h / 0 °C 2.1: N,N-diethylaniline; trichlorophosphate / 3 h / Reflux View Scheme

1.1: sodium acetate; sodium hydroxide / ethanol; water / 20 °C 1.2: 0.5 h / 0 °C 1.3: 0 - 5 °C 2.1: pyridine; trichlorophosphate / toluene / 4.75 h / 70 °C 3.1: ammonium formate; zinc / methanol; isopropyl alcohol / 0.33 h 4.1: hydrogen / 11 h / 20 °C View Scheme