3,5-二氨基-6-氯吡嗪-2-羧酸甲酯合成路线 （共 6 条）
反应条件
in chloroform 17 h; Heating;
参考文献
Goerlitzer, Klaus; Huth, Silke; Goessnitzer, Edith; Wendelin, Winfried
Scientia Pharmaceutica, 2004 , vol. 72, # 2 p. 109 - 120
反应条件
sodium in ethanol
Reflux;
参考文献
Matthews, Hayden; Ranson, Marie; Tyndall, Joel D.A.; Kelso, Michael J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6760 - 6766
反应条件
1: With lithium hydroxide; water in methanol
T=90°C; 1.5 h;
2: With hydrogenchloride in 1,4-dioxane; water
T=100°C; 2 h;
3: With sodium carbonate in water
pH=8;
参考文献
PFIZER LIMITED
Patent: WO2008/135830 A1, 2008 ;
Location in patent: Page/Page column 61 ;
WO 2008/135830 A1
反应条件
1: With methanol; lithium hydroxide; water in tetrahydrofuran
T=20°C; 72 h;
2: With hydrogenchloride; water in tetrahydrofuran; methanol
参考文献
NOVARTIS VACCINES AND DIAGNOSTICS, INC.
Patent: WO2008/106692 A1, 2008 ;
Location in patent: Page/Page column 121 ;
WO 2008/106692 A1
反应条件
in diethylene glycol dimethyl ether
T=100°C; 16 h;
参考文献
Shutske
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 5 p. 1017 - 1023
反应条件
hydrazine hydrate in ethanol
Reflux;
参考文献
Matthews, Hayden; Ranson, Marie; Tyndall, Joel D.A.; Kelso, Michael J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6760 - 6766
