3-氨基-5,6-二氯-2-吡嗪羧酸甲脂合成路线 （共 3 条）
反应条件
1: ammonia / 11.5 h / -80 °C / Inert atmosphere; Reflux 2: trichlorophosphate / toluene / 5 h / 80 °C / Inert atmosphere View Scheme
参考文献
Massey, Archna P.; Harley, William R.; Pasupuleti, Nagarekha; Gorin, Fredric A.; Nantz, Michael H.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2635 - 2639
参考文献
ARDEA BIOSCIENCES INC.
Patent: WO2009/89263 A2, 2009 ;
Location in patent: Page/Page column 126 ;
反应条件
1: With sodium hydroxide; water
0.25 h; Heating / reflux;
2: With hydrogenchloride in water
T=20°C;
参考文献
SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2006/88920 A1, 2006 ;
Location in patent: Page/Page column 147 ;
WO 2006/088920 A1
