5-氯-2-乙基-1H-咪唑-4-羧醛合成路线 （共 10 条）
反应条件
manganese(IV) oxide in 1,4-dioxane; dichloromethane 9 h; Heating;
参考文献
Davood, Asghar; Mansouri, Niloufar; Dehpour, Ahmad Rerza; Shafaroudi, Hamed; Alipour, Eskandar; Shafiee, Abbas
Archiv der Pharmazie, 2006 , vol. 339, # 6 p. 299 - 304
反应条件
manganese(IV) dioxide in dichloromethane
参考文献
Glaxo Group Limited
Patent: US5374646 A1, 1994 ;
US 5374646 A
反应条件
1: 56 percent / N-chlorosuccinimide / 2-methoxy-ethanol; dioxane / 24 h / 20 °C 2: 98 percent / MnO2 / CH2Cl2; dioxane / 9 h / Heating View Scheme
参考文献
Judd; Dowle; Middlemiss; Scopes; Ross; Jack; Pass; Tranquillini; Hobson; Panchal; Stuart; Paton; Hubbard; Hilditch; Drew; Robertson; Clark; Travers; Hunt; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 19 p. 3108 - 3120
反应条件
1: triphenylphosphine; tetrachloromethane / acetonitrile / 4.5 h / 45 °C 2: methanesulfonic acid / chloroform / 1 h / 20 °C 3: manganese(IV) oxide / 1,4-dioxane / 6.5 h / |Reflux View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/154271 A1, 2008 ;
反应条件
1: methanesulfonic acid / chloroform / 1 h / 20 °C 2: manganese(IV) oxide / 1,4-dioxane / 6.5 h / |Reflux View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/154271 A1, 2008 ;
反应条件
1: Br2 / ethanol / 3 h / Ambient temperature 2: Na2SO3, aq. NaOH / ethanol / 18 h / Heating 3: aq. NaOH / ethanol / Ambient temperature 4: MnO2 / CH2Cl2; dioxane / Heating 5: conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Watson
Synthetic Communications, 1992 , vol. 22, # 20 p. 2971 - 2977
反应条件
1: aq. NaOH / ethanol / Ambient temperature 2: MnO2 / CH2Cl2; dioxane / Heating 3: conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Watson
Synthetic Communications, 1992 , vol. 22, # 20 p. 2971 - 2977
反应条件
1: MnO2 / CH2Cl2; dioxane / Heating 2: conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Watson
Synthetic Communications, 1992 , vol. 22, # 20 p. 2971 - 2977
反应条件
1: Na2SO3, aq. NaOH / ethanol / 18 h / Heating 2: aq. NaOH / ethanol / Ambient temperature 3: MnO2 / CH2Cl2; dioxane / Heating 4: conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Watson
Synthetic Communications, 1992 , vol. 22, # 20 p. 2971 - 2977
反应条件
hydrogenchloride 24 h; Heating; Yield given;
参考文献
Watson
Synthetic Communications, 1992 , vol. 22, # 20 p. 2971 - 2977
