1,1-二甲基呋喃并[3,4-c]吡啶-3,4(1H,5H)-二酮合成路线 （共 10 条）
反应条件
1: 2-methyl-2-hydroxy-butan-3-one; diethyl malonate With sodium ethanolate in ethanol T=20°C; 0.5 h; 2: 5-azapyrimidine in ethanol T=20°C; 3 h;
参考文献
Villemin, Didier; Cheikh, Nawel; Liao, Liang; Bar, Nathalie; Lohier, Jean-Francois; Sopkova, Jana; Choukchou-Braham, Noureddine; Mostefa-Kara, Bachir
Tetrahedron, 2012 , vol. 68, # 24 p. 4906 - 4918
反应条件
sodium ethanolate in ethanol T=20°C; 1 h;
参考文献
Villemin, Didier; Liao, Liang
Tetrahedron Letters, 1996 , vol. 37, # 48 p. 8733 - 8734
反应条件
hydrogenchloride in water T=85 - 90°C; pH=4 - 5; 3 h;
参考文献
Avetisyan; Karapetyan; Tadevosyan
Russian Journal of Organic Chemistry, 2010 , vol. 46, # 8 p. 1259 - 1261
反应条件
1: 2-methoxypyridine-3-carboxylic acid With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: acetone in tetrahydrofuran; hexane T=-78°C; 0.5 h; 3: With hydrogenchloride; acetic acid in ethanol Heating;
参考文献
Tetrahedron Letters, , vol. 46, # 22 p. 3811 - 3813
反应条件
1: 2-methoxypyridine-3-carboxylic acid With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: acetone in tetrahydrofuran; hexane T=-78°C; 0.5 h; 3: With sulfuric acid; acetic acid in ethanol 3 h; Heating;
参考文献
Tetrahedron Letters, , vol. 46, # 22 p. 3811 - 3813
参考文献
Guillier, Fabricee; Nivoliers, Francois; Bourguignon, Jean; Dupas, Georges; Marsais, Francis; Godard, Alain; Queguiner, Guy
Tetrahedron Letters, 1992 , vol. 33, # 48 p. 7355 - 7356
反应条件
hydrogenchloride; acetic acid 4 h; Reflux;
参考文献
Pham, The Hien; Hovhannisyan, Anna; Bouvier, Dominique; Tian, Lei; Reboud-Ravaux, Michele; Melikyan, Gagik; Bouvier-Durand, Michelle
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3822 - 3827
反应条件
1: 85 percent / Cs2CO3, Aliquat 336 / ethanol / 0.67 h / 20 °C 2: 90 percent / EtONa / ethanol / 1 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 48 p. 8733 - 8734
反应条件
1: anhydrous xylene / 3 h / Reflux 2: hydrogenchloride; acetic acid / 4 h / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 11 p. 3822 - 3827
反应条件
sodium carbonate in ethanol
Heating;
参考文献
Guillier, Fabricee; Nivoliers, Francois; Bourguignon, Jean; Dupas, Georges; Marsais, Francis; Godard, Alain; Queguiner, Guy
Tetrahedron Letters, 1992 , vol. 33, # 48 p. 7355 - 7356
