双环[2.2.2]辛烷-1,4-二羧酸二甲酯合成路线 （共 19 条）
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide in tetrahydrofuran
参考文献
Della, Ernest W.; Tsanaktsidis, John
Australian Journal of Chemistry, 1985 , vol. 38, # 11 p. 1705 - 1718
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide in tetrahydrofuran -78 deg C to RT;
参考文献
Richard Baker; Hancox, Timothy C.
Tetrahedron Letters, 1999 , vol. 40, # 4 p. 781 - 784
反应条件
1: With N,N,N',N'-tetramethyl-urea; lithium diisopropyl amide in tetrahydrofuran T=-78 - 25°C; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
US6649600 B1, ;
Page/Page column 60 ;
US 6649600 B1
反应条件
ethanol; Raney nickel-W2 96 h; Heating;
参考文献
Nuding; Voegtle; Danielmeier; Steckhan
Synthesis, 1996 , # 1 p. 71 - 76
反应条件
1: 88.9 percent / BF3*Et2O / acetic acid / 24 h 2: 89.2 percent / EtOH / Raney nickel-W2 / 96 h / Heating View Scheme
参考文献
Synthesis, , # 1 p. 71 - 76
反应条件
1: 1.) NaH / 1.) 1,2-dimethoxyethane, 2.) 1,2-dimethoxyethane, reflux 2: 88.9 percent / BF3*Et2O / acetic acid / 24 h 3: 89.2 percent / EtOH / Raney nickel-W2 / 96 h / Heating View Scheme
参考文献
Synthesis, , # 1 p. 71 - 76
反应条件
2: Py / Heating 3: 165 °C / 760000 Torr 4: H2 / Pd-C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 35, p. 917 - 923
反应条件
1: Py / Heating 2: 165 °C / 760000 Torr 3: H2 / Pd-C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 35, p. 917 - 923
反应条件
1.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere 1.2: -78 - 20 °C 2.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - 20 °C / Inert atmosphere View Scheme
反应条件
potassium hydride in tetrahydrofuran; pentane a) from -25 to -20 deg C, 5 min, b) from - 20 deg C to RT, 12 h;
参考文献
Australian Journal of Chemistry, , vol. 38, # 11 p. 1705 - 1718
