双环[2.2.2]辛烷-1,4-二羧酸二甲酯合成路线

619-81-8顺-1,4-环己烷二甲酸

1459-96-7双环[2.2.2]辛烷-1,4-二羧酸二甲酯

参考文献

WO2012/145569 A1, ;

1459-96-7双环[2.2.2]辛烷-1,4-二羧酸二甲酯

23062-52-4

参考文献

Chapman,N.B. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 917 - 923

1459-96-7双环[2.2.2]辛烷-1,4-二羧酸二甲酯

711-02-4二环[2,2,2]辛烷-1,4-环己二羧酸

参考文献

ROYALTY, Susan Marie; BURNS, James Ford; SCICINSKI, Jan Jozef; FOGLESONG, Robert James; JAGDMANN, JR., Gunnar Erik; GRIFFIN, Kellee Renee; DYAKONOV, Tatyana; MIDDLEMISS, David
Patent: WO2006/12441 A1, 2006 ;
Location in patent: Page/Page column 33-34 ;
WO 2006/012441 A1

1459-96-7双环[2.2.2]辛烷-1,4-二羧酸二甲酯

711-02-4二环[2,2,2]辛烷-1,4-环己二羧酸+

18720-35-94-(甲氧羰基)双环[2.2.2]辛烷-1-羧酸

参考文献

Della, Ernest W.; Tsanaktsidis, John
Australian Journal of Chemistry, 1986 , vol. 39, p. 2061 - 2066

1459-96-7双环[2.2.2]辛烷-1,4-二羧酸二甲酯

18720-35-94-(甲氧羰基)双环[2.2.2]辛烷-1-羧酸

参考文献

ALANTOS PHARMACEUTICALS HOLDING, INC.
Patent: WO2008/63671 A2, 2008 ;
Location in patent: Page/Page column 177-178 ;
WO 2008/063671 A2

1459-96-7双环[2.2.2]辛烷-1,4-二羧酸二甲酯

711-02-4二环[2,2,2]辛烷-1,4-环己二羧酸+

18720-35-94-(甲氧羰基)双环[2.2.2]辛烷-1-羧酸

参考文献

Della, Ernest W.; Tsanaktsidis, John
Australian Journal of Chemistry, 1986 , vol. 39, p. 2061 - 2066

1459-96-7双环[2.2.2]辛烷-1,4-二羧酸二甲酯

1127-13-54-羟基双环[2.2.2]辛烷-1-羧酸

参考文献

SIGNAL PHARMACEUTICALS, LLC; BENNETT, Brydon, L.; ELSNER, Jan; ERDMAN, Paul; HILGRAF, Robert; LEBRUN, Laurie, Ann; MCCARRICK, Meg; MOGHADDAM, Mehran, F.; NAGY, Mark, A.; NORRIS, Stephen; PAISNER, David, A.; SLOSS, Marianne; ROMANOW, William, J.; SATOH, Yoshitaka; TIKHE, Jayashree; YOON, Won, Hyung; DELGADO, Mercedes
Patent: WO2012/145569 A1, 2012 ;

1459-96-7双环[2.2.2]辛烷-1,4-二羧酸二甲酯

23062-53-54-羟基双环[2.2.2]辛烷-1-羧酸甲酯

参考文献

Chapman,N.B. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 917 - 923

1459-96-7双环[2.2.2]辛烷-1,4-二羧酸二甲酯

94994-15-74-(羟基甲基)双环[2.2.2]辛烷-1-羧酸甲酯

参考文献

Richard Baker; Hancox, Timothy C.
Tetrahedron Letters, 1999 , vol. 40, # 4 p. 781 - 784