(S)-(+)-2,2-二甲基环丙甲酸合成路线 （共 8 条）
反应条件
dipotassium hydrogenphosphate; water; esterase T=40°C; pH=7; Aqueous phophate buffer;
参考文献
CLS LABORATORIES, INC.
Patent: WO2004/5241 A1, 2004 ;
Location in patent: Page 9-10 ;
反应条件
1: 50 percent / pyridinium tosylate / benzene / 24 h / Heating 2: 81 percent / diethylzinc / 1,2-dichloro-ethane; hexane / 24 h / 0 °C 3: 79 percent / O3 / ethyl acetate / 1 h / 23 °C 4: 2 N aq. NaOH / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 3 p. 564 - 577
反应条件
1: 81 percent / diethylzinc / 1,2-dichloro-ethane; hexane / 24 h / 0 °C 2: 79 percent / O3 / ethyl acetate / 1 h / 23 °C 3: 2 N aq. NaOH / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 3 p. 564 - 577
反应条件
Flavobacterium aquatile strain ZJB-09211 in water T=30°C; Microbiological reaction; enantioselective reaction;
参考文献
Chemical Papers, , vol. 67, # 10 p. 1262 - 1270
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 6 p. 1074 - 1090
参考文献
Tetrahedron Letters, , vol. 38, # 22 p. 3959 - 3962
反应条件
1: 93 percent / pyridine / 1.5 h / Ambient temperature 2: 83 percent / 3 M NH3 / ethanol / 0.75 h 3: 28 percent / toluene / Heating 4: 1.) NH3 (liq.), Na / 2.) MeOH, 45 deg C, 15 min View Scheme
参考文献
Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1074 - 1090
反应条件
1: With thionyl chloride in dichloromethane T=20°C; 2: With ammonia in dichloromethane T=-15°C;
参考文献
CLS LABORATORIES, INC.
Patent: WO2004/5241 A1, 2004 ;
Location in patent: Page 10 ;
