1H-吡咯[2,3-B]吡啶-6-胺合成路线 （共 5 条）
反应条件
1.1: diethyl ether / 5 h / 20 °C 2.1: dimethyl sulfate / acetonitrile / 8 h / 70 °C 2.2: 48 h / 50 - 60 °C / Inert atmosphere; sealed tube View Scheme
反应条件
1: With dimethyl sulfate in acetonitrile T=70°C; 8 h; 2: With ammonia in methanol; acetonitrile T=50 - 60°C; 48 h; Inert atmosphereSealed tube;
参考文献
AC IMMUNE S.A.; KROTH, Heiko; HAMEL, Cotinica; BENDERITTER, Pascal; FROESTL, Wolfgang; SREENIVASACHARY, Nampally; MUHS, Andreas
Patent: WO2011/128455 A1, 2011 ;
Location in patent: Page/Page column 86 ;
WO 2011/128455 A1
反应条件
ammonium hydroxide T=200°C; 12 h;
参考文献
Minakata, Satoshi; Itoh, Shinobu; Komatsu, Mitsuo; Ohshiro, Yoshiki
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 11 p. 2992 - 2997
反应条件
1.1: ethyl acetate / 19 h / 25 - 60 °C 2.1: n-butyllithium / tetrahydrofuran; N,N-dimethyl-formamide; hexane / 17.5 h / -15 - 25 °C 3.1: ethyl acetate / 16 h / 0 - 25 °C 4.1: ammonia; dimethyl sulfate / dichloromethane; methanol; acetonitrile; ethyl acetate / 16 h / 60 °C 4.2: 16 h / 55 °C / |Sealed tube View Scheme
反应条件
1.1: n-butyllithium / tetrahydrofuran; N,N-dimethyl-formamide; hexane / 17.5 h / -15 - 25 °C 2.1: ethyl acetate / 16 h / 0 - 25 °C 3.1: ammonia; dimethyl sulfate / dichloromethane; methanol; acetonitrile; ethyl acetate / 16 h / 60 °C 3.2: 16 h / 55 °C / |Sealed tube View Scheme
