3-氨基-3-苯基-1-丙醇合成路线 （共 25 条）
反应条件
1: 57 percent / NaHCO3 / tetrahydrofuran; H2O / 22 h / 20 °C 2: 87 percent / pyridine / CH2Cl2 / 2 h / 0 - 20 °C View Scheme
参考文献
Torre, Oliver; Gotor-Fernandez, Vicente; Gotor, Vicente
Tetrahedron Asymmetry, 2006 , vol. 17, # 5 p. 860 - 866
反应条件
1: 80 percent / aq. NaOH / 4 h / 20 °C 2: 45 percent / penicillin G acylase immobilized on epoxy-resin; phosphate buffer / ethanol; H2O / 1 h / 25 °C / pH 7.5 View Scheme
参考文献
Fadnavis, Nitin W.; Radhika, Kasiraman R.; Vedamayee Devi
Tetrahedron Asymmetry, 2006 , vol. 17, # 2 p. 240 - 244
反应条件
triethylamine in ethyl acetate
72 h; Yield given. Yields of byproduct given;
参考文献
Boyd, Victoria L.; Zon, Gerald; Himes, Vicky L.; Stalick, Judith K.; Mighell, Alan D.; Secor, Henry V.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 372 - 375
反应条件
1: 80 percent / aq. NaOH / 4 h / 20 °C
2: 47.5 percent / penicillin G acylase immobilized on epoxy-resin; phosphate buffer / ethanol; H2O / 1 h / 25 °C / pH 7.5
3: 100 percent / aq. HCl / Heating
View Scheme
参考文献
Fadnavis, Nitin W.; Radhika, Kasiraman R.; Vedamayee Devi
Tetrahedron Asymmetry, 2006 , vol. 17, # 2 p. 240 - 244
反应条件
1.1: sodium carbonate / ethyl acetate; water / 2 h / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -50 °C
2.2: 0.58 h / -50 - 20 °C
3.1: triethylamine; lithium chloride / acetonitrile / 18 h / 20 °C
4.1: hydrogen / palladium 10 on activated carbon / ethanol / 4 h / 65 °C / 2327.23 Torr
View Scheme
参考文献
Brotherton-Pleiss, Christine E.; Harris, III, Ralph New; Loe, Bradley E.; Lopez-Tapia, Francisco Javier; Rege, Pankaj D.; Repke, David Bruce; Stabler, Russell Stephen; Walker, Keith Adrian Murray
Patent: US2011/71143 A1, 2011 ;
