反应条件
1: 1.) O3, 2.) thiourea / 1.) MeOH, -78 deg C
2: 1.) n-BuLi / 1.) THF, -78 deg C, 5 min., 2.) a) THF, -78 deg C, 5 min., b) AcOH-THF, -78 deg C -> r.t.
3: 99 percent / conc. H2SO4 / acetonitrile; H2O / 65 °C
4: 81 percent / pyridinium dichromate, 4 Angstroem sieves / CH2Cl2 / Ambient temperature
5: 1.) DBU, 2.) AcOH-THF / 1.) CH2Cl2, -78 deg C, 2.) -78 deg C to r.t.
View Scheme
参考文献
Craig, Donald; Etheridge, Christopher J.; Smith, Alison M.
Tetrahedron Letters, 1992 , vol. 33, # 48 p. 7445 - 7446
