5-氨基噻吩-2-甲酸甲酯合成路线 （共 6 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=760.051 Torr;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/65788 A2, 2006 ;
Location in patent: Page/Page column 10 ;
WO 2006/065788 A2
反应条件
1: With sulfuric acid; nitric acid T=0 - 10°C; 2: With methanol; thionyl chloride T=20°C; Reflux; 3: With hydrogenchloride; iron; ammonium chloride in methanol; water T=20 - 70°C;
参考文献
US2010/68178 A1, ;
Page/Page column 16-17 ;
反应条件
1: thiophene-2-carboxylic acid With sulfuric acid; nitric acid T=0 - 10°C; 1.25 h; 2: methanol With thionyl chloride T=20°C; Reflux;
参考文献
WO2010/29577 A2, ;
Page/Page column 38-39 ;
反应条件
1: SOCl2 2: Fe; AcOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 10 p. 1379 - 1382
反应条件
1: dichloromethane / 0 - 20 °C 2: Pearlman's catalist; hydrogen / ethanol View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 9 p. 708 - 713
