1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 20 - 80 °C / |Schlenk technique; |Inert atmosphere 2: sodium hydroxide; water / tetrahydrofuran / 80 °C View Scheme

isopropylmagnesium chloride in tetrahydrofuran T=0 - 20°C; 0.666667 h;

copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); cesium fluoride in N,N-dimethyl-formamide T=115°C; 0.75 h; Inert atmosphere;

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / 0 °C 1.2: 0.5 h / 0 - 20 °C 2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / water; 2-methyl tetrahydrofuran / 2.5 h / 74 °C View Scheme

1: triethylamine / dichloromethane / 0 - 20 °C 2: sodium acetate / water; tert-butyl alcohol / 288 h / 110 °C View Scheme