(5Z,8Z,11Z)-5,8,11-二十碳三烯酸甲酯合成路线 （共 6 条）
反应条件
hydrogen; ethylenediamine; sodium tetrahydroborate; nickel diacetate in ethanol
参考文献
Jeffery, Tuyet; Gueugnot, Sylvie; Linstrumelle, Gerard
Tetrahedron Letters, 1992 , vol. 33, # 39 p. 5757 - 5760
反应条件
1: 87 percent / copper(I) iodide, sodium carbonate, tetra-n-butylammonium chloride / dimethylformamide / 23 h / 20 °C 2: 86 percent / CBr4, PPh3 / CH2Cl2 / 1.5 h / 0 °C 3: 51 percent / copper(I) iodide, sodium carbonate, tetra-n-butylammonium chloride / dimethylformamide / 23 h / 20 °C 4: 73 percent / H2, H2N(CH2)2NH2 / Ni(OAc)2*4H2O, NaBH4 / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 39 p. 5757 - 5760
反应条件
1: 51 percent / copper(I) iodide, sodium carbonate, tetra-n-butylammonium chloride / dimethylformamide / 23 h / 20 °C 2: 73 percent / H2, H2N(CH2)2NH2 / Ni(OAc)2*4H2O, NaBH4 / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 39 p. 5757 - 5760
反应条件
1: 86 percent / CBr4, PPh3 / CH2Cl2 / 1.5 h / 0 °C 2: 51 percent / copper(I) iodide, sodium carbonate, tetra-n-butylammonium chloride / dimethylformamide / 23 h / 20 °C 3: 73 percent / H2, H2N(CH2)2NH2 / Ni(OAc)2*4H2O, NaBH4 / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 39 p. 5757 - 5760
反应条件
1: (i) EtMgBr, THF, (ii) CuCN, (iii) /BRN= 1817884/ 2: (i) H2, quinoline, Lindlar catalyst, PE, (ii) /BRN= 102415/ View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 85, p. 1233 - 1250
反应条件
(i) H2, quinoline, Lindlar catalyst, PE, (ii) /BRN= 102415/; Multistep reaction;
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 85, p. 1233 - 1250
