2-(3-异丙氧基苯基)乙酸合成路线 (共 2 条)
反应条件
1: 2-(3-hydroxyphenyl)acetic acid With acetyl chloride in methanol 4 h; Heating / reflux; 2: 2-iodo-propane With potassium carbonate in DMF (N,N-dimethyl-formamide) T=50°C; 1 h; 3: With sodium hydroxide in methanol; water 2 h; Heating / reflux;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/101528 A2, 2004 ;
Location in patent: Page 96 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide 29 h; Heating;
参考文献
Solladie, Guy; Pasturel-Jacope, Yacine; Maignan, Jean
Tetrahedron, 2003 , vol. 59, # 18 p. 3315 - 3321