1: NaOAc / ethanol / 4 h / Heating 2: 2N HCl / 20 h / Heating View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1: 32 percent / H₂O / 8 h / 150 - 160 &deg;C<br />2: 71 percent / NaH / dimethylformamide / 1 h<br />3: H₂ / 5percent Pd/C / ethyl acetate / 760 Torr<br />4: 1.) aq. HBr, NaNO₂, 2.) Cu₂O / 1.) acetone, 5 deg C, 2.) acetone<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 71 percent / NaH / dimethylformamide / 1 h<br />2: H₂ / 5percent Pd/C / ethyl acetate / 760 Torr<br />3: 1.) aq. HBr, NaNO₂, 2.) Cu₂O / 1.) acetone, 5 deg C, 2.) acetone<br /> <br /> &nbsp;