三(苄氧羰基)-L-精氨酸合成路线 （共 16 条）
反应条件
1: chlorocarbonic acid isobutyl ester
2: palladium; ethanol / Hydrogenation.weiteres Reagens: Essigsaeure
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参考文献
Zervas et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2878,2881
反应条件
1: triethylamine; chlorocarbonic acid isobutyl ester; CHCl3 / weiteres Reagens: Toluol; anschliessend Behandeln mit L-Leucin-benzylester-toluol-4-sulfonat und Triaethylamin in CHCl3
2: palladium; methanol. acetic acid / Hydrogenation
View Scheme
参考文献
Zervas et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2878,2881
反应条件
1: 66 percent / 1-hydroxybenzotriazole, Et3N / dimethylformamide / 2 h / 18 °C
2: 85 percent / HCOONH4 / Pd/C / ethanol / 1 h / cyclohexene and Pd-black was used as well
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参考文献
Kulikov, S. V.; Sokolova, N. Yu.; Samartsev, M. A.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, p. 1625 - 1631
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 8 p. 1779 - 1787
反应条件
1: triethylamine; chlorocarbonic acid isobutyl ester; CHCl3 / weiteres Reagens: Toluol; anschliessend Behandeln mit L-Isoleucin-benzylester-toluol-4-sulfonat und Triaethylamin in CHCl3
2: palladium/charcoal; methanol. acetic acid / Hydrogenation
View Scheme
参考文献
Zervas et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2878,2881
反应条件
1: 1) Et3N, isobutyl chloroformate or pivaloyl chloride 2) Et3N / 1) CHCl3, -10 deg C 2) 0 deg C, 1 h, then 18-25 deg C, 16 h
2: 96 percent / HCOONH4 / Pd/C / ethanol / 1 h / H2/Pd was tested as well
View Scheme
参考文献
Kulikov, S. V.; Sokolova, N. Yu.; Samartsev, M. A.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, p. 1625 - 1631
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 8 p. 1779 - 1787
反应条件
thionyl chloride
Behandeln einer Loesung des Reaktionsprodukts in Aceton mit konz. wss. HCl;
参考文献
Zervas et al.
Journal of Organic Chemistry, 1957 , vol. 22, p. 1515,1518
Journal of the American Chemical Society, 1959 , vol. 81, p. 2878,2883
