2-氟-6-甲氧基苯甲醛合成路线 （共 16 条）
反应条件
1: 1-fluoro-3-methoxybenzene With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane 1 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexane
参考文献
Rhizen Pharmaceuticals SA
Patent: US2012/289496 A1, 2012 ;
Location in patent: Page/Page column 100 ;
反应条件
diisobutylaluminium hydride in hexane; toluene T=-78 - 20°C; Reduction;
参考文献
Smith III, Amos B.; Wan, Zehong
Organic Letters, 1999 , vol. 1, # 9 p. 1491 - 1494
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; n-heptane; N,N-dimethyl-formamide
参考文献
US2002/156081 A1, ;
US 20020156081 A1
反应条件
n-butyllithium in tetrahydrofuran; N-methyl-acetamide; water
反应条件
1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C 2: triphenylphosphine; carbon tetrabromide / dichloromethane / 2 h / 20 °C View Scheme
反应条件
n-butyllithium; bromine; iron 1.) CCl4, -60 deg C, 2 h, 2.) Et2O, -55 deg C; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 1 p. 72 - 83
反应条件
hydrazine hydrate in ethylene glycol dimethyl ether 15 h; Heating;
参考文献
Lukin, Kirill; Hsu, Margaret C.; Fernando, Dilinie; Leanna, M. Robert
Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8166 - 8172
反应条件
1: With boron tribromide in dichloromethane T=5°C; 2 h; Cooling with acetone-dry ice; 2: With sodium hydroxide in dichloromethane; water T=0°C; pH=6.5;
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD
Patent: WO2004/45610 A1, 2004 ;
Location in patent: Page/Page column 137-138 ;
WO 2004/045610 A1
反应条件
1: 89 percent / NH2OH*HCl, NaHCO3 / H2O; ethanol / 2 h / 25 °C 2: 84 percent / Ac2O / 4 h / Heating View Scheme
参考文献
Bridges, Alexander J.; Zhou, Hairong
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1163 - 1172
反应条件
1.1: magnesium / diethyl ether / 12 h / 20 °C 1.2: 0 °C 2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C 3.1: AlCl3, aluminium chloride / dichloromethane / 12 h / 20 °C View Scheme
参考文献
Rhizen Pharmaceuticals SA
Patent: US2012/289496 A1, 2012 ;
