2-氟-6-甲氧基苯甲醛合成路线 （共 16 条）
反应条件
potassium permanganate in water; acetone Oxidation; 3 h; Heating;
参考文献
Smith III, Amos B.; Wan, Zehong
Organic Letters, 1999 , vol. 1, # 9 p. 1491 - 1494
反应条件
1: 89 percent / NH2OH*HCl, NaHCO3 / H2O; ethanol / 2 h / 25 °C 2: 84 percent / Ac2O / 4 h / Heating 3: 1.) NaH / 1.) DMSO, 25 deg C, 2.) DMSO, 3 h View Scheme
参考文献
Bridges, Alexander J.; Zhou, Hairong
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1163 - 1172
反应条件
1.1: magnesium / diethyl ether / 12 h / 20 °C 1.2: 0 °C 2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C View Scheme
参考文献
Rhizen Pharmaceuticals SA
Patent: US2012/289496 A1, 2012 ;
反应条件
sodium hydride 1.) DMSO, 20 deg C, 2.) DMSO, 2-5 min; Yield given. Multistep reaction;
参考文献
Lee, Sunkyung; Lee, Hyunsuk; Kyu, Yang Yi; Byung, Ho Lee; Yoo, Sung-Eun; Lee, Kyunghee; Nam, Sook Cho
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 2998 - 3001
反应条件
hydroxylamine hydrochloride; sodium hydrogencarbonate in ethanol; water T=25°C; 2 h;
参考文献
Bridges, Alexander J.; Zhou, Hairong
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1163 - 1172
反应条件
1.1: magnesium / diethyl ether / 12 h / 20 °C
1.2: 0 °C
2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C
3.1: AlCl3, aluminium chloride / dichloromethane / 12 h / 20 °C
4.1: pyridine / dichloromethane / 3 h / 45 °C / Cooling with ice
5.1: sodium hydride / dimethyl sulfoxide / 12 h / 100 °C
6.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 - 60 °C
View Scheme
参考文献
Rhizen Pharmaceuticals SA
Patent: US2012/289496 A1, 2012 ;
