4-碘苯并[b]噻吩-2-羧酸甲酯合成路线 （共 5 条）
反应条件
tert.-butyl lithium; lithium chloride; bis(triphenylphosphine)palladium(II)-chloride in N,N,N',N',N'',N''-hexamethylphosphoric triamide; N,N-dimethyl-formamide
参考文献
US5340833 A1, ;
US 5340833 A
反应条件
ammonium chloride in methanol; chloroform; toluene
参考文献
Eisai Co., Ltd.
Patent: US5340833 A1, 1994 ;
US 5340833 A
反应条件
triethylamine in dimethyl sulfoxide
T=70 - 100°C;
参考文献
Bridges, Alexander J.; Lee, Arthur; Maduakor, Emmanuel C.; Eric Schwartz
Tetrahedron Letters, 1992 , vol. 33, # 49 p. 7499 - 7502
参考文献
Eisai Co., Ltd.
Patent: US5340833 A1, 1994 ;
US 5340833 A
反应条件
1.1: LDA / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran
2.1: K2CO3 / dimethylformamide
View Scheme
参考文献
Lee, Sunkyung; Lee, Hyunsuk; Kyu, Yang Yi; Byung, Ho Lee; Yoo, Sung-Eun; Lee, Kyunghee; Nam, Sook Cho
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 2998 - 3001
