(6-氨基吡嗪-3-基)(苯基)甲酮合成路线 （共 4 条）
反应条件
ammonia T=100°C; 36 h;
参考文献
Mourad; Wise; Townsend
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1583 - 1592
反应条件
1.1: tBuOK / N,N-dimethyl-acetamide / 0.5 h / 0 °C 1.2: N,N-dimethyl-acetamide / 1 h / 20 °C 1.3: aq. H2O2 / N,N-dimethyl-acetamide / 1 h / 0 °C 2.1: 75 percent / NH3 / ethanol / 16 h / 145 °C View Scheme
参考文献
Hamdouchi, Chafiq; Sanchez-Martinez, Concha; Gruber, Joseph; Del Prado, Miriam; Lopez, Javier; Rubio, Almudena; Heinz, Beverly A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4333 - 4341
反应条件
1: thionyl chloride / 2 h / Heating 2: 89 percent / aluminum chloride / 6 h / Heating 3: 95 percent / ammonia / 36 h / 100 °C View Scheme
参考文献
Mourad; Wise; Townsend
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1583 - 1592
反应条件
1: 89 percent / aluminum chloride / 6 h / Heating 2: 95 percent / ammonia / 36 h / 100 °C View Scheme
参考文献
Mourad; Wise; Townsend
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1583 - 1592
