反应条件
1: 2-lt;3-(carboxymethyl)phenylgt;propionitrile With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.5 h;
2: methyl iodide in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
Galemmo, JR., Robert; Holland, Richard; Hum, Gabriel; Pajouhesh, Hossein; Chahal, Navjot; Seid-Bagherzadeh, Mehran; Girard, Amy
Patent: US2009/270394 A1, 2009 ;
Location in patent: Page/Page column 12 ;
US 20090270394 A1
