4-氯-5-甲氧基-2-甲基-2,3-二氢哒嗪-3-酮合成路线 （共 16 条）
反应条件
in methanol
T=20°C; 4.33333 h;
参考文献
F. HOFFMANN-LA ROCHE AG; JAESCHKE, Georg; LINDEMANN, Lothar; VIEIRA, Eric; WICHMANN, Juergen
Patent: WO2011/6910 A1, 2011 ;
Location in patent: Page/Page column 23 ;
WO 2011/006910 A1
参考文献
Jaeschke, Georg; Lindemann, Lothar; Vieira, Eric; Wichmann, Juergen
Patent: US2011/15202 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=50 - 60°C; 2 h;
参考文献
Li, Qin; Lin, Guichun; Liu, Li; Yang, Zhenjun; Zhang, Li-He
Molecules, 2009 , vol. 14, # 2 p. 777 - 784
反应条件
sodium methylate in methanol
参考文献
Wriede; Ulrich; Wuerzer; Bruno; Meyer; Norbert; Westphalen; Karl-Otto
Patent: US5123952 A1, 1992 ;
反应条件
18-crown-6 ether; potassium carbonate in N,N-dimethyl-formamide
T=120°C; 20 h;
参考文献
Li, Qin; Lin, Guichun; Liu, Li; Yang, Zhenjun; Zhang, Li-He
Molecules, 2009 , vol. 14, # 2 p. 777 - 784
反应条件
18-crown-6 ether; potassium carbonate in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=60°C; 24 h;
参考文献
Li, Qin; Lin, Guichun; Liu, Li; Yang, Zhenjun; Zhang, Li-He
Molecules, 2009 , vol. 14, # 2 p. 777 - 784
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
Li, Qin; Lin, Guichun; Liu, Li; Yang, Zhenjun; Zhang, Li-He
Molecules, 2009 , vol. 14, # 2 p. 777 - 784
反应条件
sodium hydroxide in water
48 h;
参考文献
Wagner, Ulrike Gabriella; Kratky, Christoph; Kappe, Thomas
Monatshefte fuer Chemie, 1989 , vol. 120, p. 329 - 342
反应条件
potassium carbonate
2.5 h; Heating;
参考文献
Chung, Hyun-A.; Kim, Jeum-Jong; Kim, Ho-Kyun; Kweon, Deok-Heon; Cho, Su-Dong; Lee, Sang-Gyeong; Yoon, Yong-Jin
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 4 p. 639 - 646
反应条件
potassium carbonate
2 h; Heating;
参考文献
Chung, Hyun-A.; Kim, Jeum-Jong; Kim, Ho-Kyun; Kweon, Deok-Heon; Cho, Su-Dong; Lee, Sang-Gyeong; Yoon, Yong-Jin
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 4 p. 639 - 646
