2-(1-苄基-4-哌啶基)-2-氰基乙酸乙酯合成路线 （共 15 条）
反应条件
acetic acid in toluene T=20°C; 4 h; Heating / reflux;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/69256 A1, 2004 ;
Location in patent: Page/Page column 41 ;
WO 2004/069256 A1
反应条件
hydrogenchloride; sodium tetrahydroborate
参考文献
Asadipour, Ali; Alipour, Masoumeh; Jafari, Mona; Khoobi, Mehdi; Emami, Saeed; Nadri, Hamid; Sakhteman, Amirhossein; Moradi, Alireza; Sheibani, Vahid; Homayouni Moghadam, Farshad; Shafiee, Abbas; Foroumadi, Alireza
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 623 - 630
反应条件
1: dichloromethane / 20 °C 2: sodium tetrahydroborate; hydrogenchloride View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 70, p. 623 - 630
反应条件
1.1: ethanol; H2O / 18 h / Heating 2.1: conc. aq. HCl / 24 h / Heating 3.1: SOCl2 4.1: DIEA / acetonitrile / 20 °C 4.2: NaOAc; Ac2O / Heating 5.1: BH3 / tetrahydrofuran / Heating 6.1: CAN / acetonitrile; H2O View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: ethanol; H2O / 18 h / Heating 2.1: conc. aq. HCl / 24 h / Heating 3.1: SOCl2 4.1: DIEA / acetonitrile / 20 °C 4.2: NaOAc; Ac2O / Heating 5.1: BH3 / tetrahydrofuran / Heating 6.1: CAN / acetonitrile; H2O 7.1: NaOH / dioxane View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: ethanol; H2O / 18 h / Heating 2.1: conc. aq. HCl / 24 h / Heating 3.1: SOCl2 4.1: DIEA / acetonitrile / 20 °C 4.2: NaOAc; Ac2O / Heating 5.1: BH3 / tetrahydrofuran / Heating 6.1: CAN / acetonitrile; H2O 7.1: NaOH / dioxane 8.1: H2 / Pd(OH)2/C / methanol / 5171.48 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1: 61 percent / ethanol; H2O / 4.5 h / Heating 2: 52 percent / lithium aluminum hydride / tetrahydrofuran / 0.25 h / Heating View Scheme
参考文献
Synthesis, , # 5 p. 388 - 389
反应条件
in ethanol; water 4.5 h; Heating;
参考文献
New, J. S.; Yevich, J. P.
Synthesis, 1983 , # 5 p. 388 - 389
反应条件
water in ethanol T=20 - 65°C; 24 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/69256 A1, 2004 ;
Location in patent: Page/Page column 41 ;
WO 2004/069256 A1
反应条件
1.1: ethanol; H2O / 18 h / Heating 2.1: conc. aq. HCl / 24 h / Heating 3.1: SOCl2 4.1: DIEA / acetonitrile / 20 °C 4.2: NaOAc; Ac2O / Heating View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
