2-(1-苄基-4-哌啶基)-2-氰基乙酸乙酯合成路线 （共 15 条）
反应条件
1: 55.10 g / ethanol; H2O / 2 h / Heating 2: 98 percent / aq. HCl / 72 h / Heating 3: DCC / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
hydrogenchloride; sodium hydroxide in N,N-dimethyl-formamide
Reflux;
参考文献
Asadipour, Ali; Alipour, Masoumeh; Jafari, Mona; Khoobi, Mehdi; Emami, Saeed; Nadri, Hamid; Sakhteman, Amirhossein; Moradi, Alireza; Sheibani, Vahid; Homayouni Moghadam, Farshad; Shafiee, Abbas; Foroumadi, Alireza
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 623 - 630
反应条件
1.1: 55.10 g / ethanol; H2O / 2 h / Heating
2.1: 98 percent / aq. HCl / 72 h / Heating
3.1: DCC / dimethylformamide / 2 h / 20 °C
4.1: Et3N / dimethylformamide / 20 °C
5.1: 3.40 g / acetic anhydride; NaOAc / 2 h / Heating
6.1: NaBH4 / methanol / 0 - 20 °C
6.2: NaBH4; TFA / 0 - 20 °C
6.3: 792 mg / acetonitrile; CH2Cl2 / 20 °C
7.1: 74 percent / aq. NH4OAc; Cd-Pb couple / tetrahydrofuran / 20 °C
8.1: 92 percent / Et3N / CH2Cl2 / 9 h / 20 °C
9.1: hydroxylamine hydrochloride; Et3N / ethanol / 20 °C
View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Smyth, Mark S.; Pandey, Anjali; Rose, Jack W.; Seroogy, Joseph M.; Volkots, Deborah L.; Nannizzi-Alaimo, Lisa; Park, Gary L.; Lambing, Joseph L.; Hollenbach, Stanley J.; Scarborough, Robert M.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2037 - 2061
反应条件
1: 55.10 g / ethanol; H2O / 2 h / Heating
2: 98 percent / aq. HCl / 72 h / Heating
View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Smyth, Mark S.; Pandey, Anjali; Rose, Jack W.; Seroogy, Joseph M.; Volkots, Deborah L.; Nannizzi-Alaimo, Lisa; Park, Gary L.; Lambing, Joseph L.; Hollenbach, Stanley J.; Scarborough, Robert M.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2037 - 2061
反应条件
1: ethanol; H2O / 18 h / Heating
2: conc. aq. HCl / 24 h / Heating
View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
