二(三甲基甲硅烷基)乙炔合成路线 （共 218 条）
反应条件
tetrabutylammomium bromide; palladium dichloride in water
T=25°C; 120 h;
参考文献
Gil-Molto, Juan; Najera, Carmen
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 14 p. 1874 - 1882
反应条件
tetrabutylammomium bromide; palladium dichloride in 1-methyl-pyrrolidin-2-one
T=100°C; 7 h; Title compound not separated from byproducts;
参考文献
Gil-Molto, Juan; Najera, Carmen
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 14 p. 1874 - 1882
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; triethylamine in N,N-dimethyl-formamide
T=70°C; 8 h; Inert atmosphere;
参考文献
Jia, Xiaodong; Petrone, David A.; Lautens, Mark
Angewandte Chemie - International Edition, 2012 , vol. 51, # 39 p. 9870 - 9872
反应条件
1: 65 percent / 1.) MeLi / tetrahydrofuran; diethyl ether / 1.) 0 deg C, 30 min; 25 deg C, 30 min; 2.) -78 deg C; 25 deg C over 2 h
2: 1.) n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h; 2.) rt, 6 h
3: LiBr / acetone / 12 h / 25 °C
4: 25 percent Chromat. / Cl2ZrCp2 / CH2Cl2 / 6 h / 25 °C
View Scheme
参考文献
Negishi,E.; Boardman,L.D.; Sawada,H.
Journal of the American Chemical Society, 1988 , vol. 110, p. 5383
反应条件
copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; (benzyl)-tri-(butyl)-ammonium chloride; sodium hydroxide; [(t-Bu)3PH]BF4 in water; toluene
T=40°C; Sonogashira coupling; 22 h; Inert atmosphere;
参考文献
Bellina, Fabio; Lessi, Marco
Synlett, 2012 , vol. 23, # 5 p. 773 - 777
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; triethylamine in N,N-dimethyl-formamide
T=70°C; 8 h; Inert atmosphere;
参考文献
Schmidt, Bernd; Berger, Rene; Kelling, Alexandra; Schilde, Uwe
Chemistry - A European Journal, 2011 , vol. 17, # 25 p. 7032 - 7040
反应条件
(Me2SiCp''2UBu)2O*2THF in tetrahydrofuran
T=66°C; 65 h; Product distribution; Further Variations:reaction time;
参考文献
Wang, Jiaxi; Gurevich, Ylia; Botoshansky, Mark; Eisen, Moris S.
Journal of the American Chemical Society, 2006 , vol. 128, # 29 p. 9350 - 9351
反应条件
1: 75 percent / AlCl3 / CH2Cl2 / 12 h / Ambient temperature
2: tetrahydrofuran / 1.) -78 deg C; 2.) up to RT
View Scheme
参考文献
Eisch, John J.; Behrooz, Mohammad; Dua, Suresh K.
Journal of Organometallic Chemistry, 1985 , vol. 285, p. 121 - 136
参考文献
Courtneidge, John L.; Davies, Alwyn G.; Lusztyk, Ewa; Lusztyk, Janusz
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , # 1 p. 155 - 164
反应条件
aluminium trichloride
参考文献
Capozzi, Giuseppe; Ottana, Rosaria; Romeo, Giovanni; Marcuzzi, Franco
Gazzetta Chimica Italiana, 1985 , vol. 115, # 6 p. 311 - 314
