1: 30percent H2O2, HCO2H / CH2Cl2 / 0.5 h / 0 °C 2: 2) 2M Na2CO3 / 1) Pd(PPh3)4 / 1) THF, 1 h, reflux, 2) 24 h, reflux 3: 80 percent / Cs2CO3 / methanol / 2 h / Ambient temperature 4: 95 percent / tetramethylguanidine / tetrahydrofuran / 1) -70 to -30 deg C, 5 h, 2) -30 deg C, 2 d, 3) RT, 15 h 5: 85 percent / H2 / (R,R)-<Rh(1,5-COD)(DIPAMP)>BF4 / methanol; CH2Cl2 / 48 h / 2250.2 Torr / Ambient temperature 6: 6M HCl / dioxane; CH2Cl2 / 0.5 h / Ambient temperature 7: hydroxybenzotriazole, N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide*HCl / CH2Cl2 / 15 h / -10 deg C to RT 8: 71 percent / HOAc / H2O / 4 h / 50 °C 9: 96 percent / Bu4NF*3H2O / dimethylformamide / 2 h / Ambient temperature 10: EDCI / CH2Cl2 / 15 h / -10 deg C to RT 11: 6M HCl / dioxane; CH2Cl2 / 0.5 h / Ambient temperature 12: aq. KHCO3 / CHCl3 / 1) RT, 2 h, 2) 50 deg C, 30 min 13: 95 percent / 1M LiOH / H2O; dioxane / 2 h / 10 °C 14: thioanisole, BrSiMe3, CF3COOH / 1 h / 0 °C View Scheme