2-[[[1-(7-氯-4-喹啉)-5-(2,6-二甲氧基苯基)-1H-吡唑-3-基]羰基]氨基]-三环[3.3.1.13,7]癸烷-2-羧酸合成路线 （共 8 条）
反应条件
QP-SA in dichloromethane T=18°C; 20 h;
参考文献
Battilocchio, Claudio; Deadman, Benjamin J.; Nikbin, Nikzad; Kitching, Matthew O.; Baxendale, Ian R.; Ley, Steven V.
Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7917 - 7930
反应条件
1: potassium hydroxide / water; tetrahydrofuran / 2 h / 120 °C / |Microwave irradiation 2: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine; bis(trichloromethyl) carbonate / dichloromethane / 18 h / 20 °C 3: QP-SA / dichloromethane / 20 h / 18 °C View Scheme
参考文献
Baxendale; Cheung; Kitching; Ley; Shearman
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4378 - 4387
反应条件
1: sodium ethanolate / ethanol / 0.42 h / 80 °C / |Microwave irradiation 2: N,N-dimethyl-formamide / 3 h / 140 °C / |Microwave irradiation 3: potassium hydroxide / water; tetrahydrofuran / 2 h / 120 °C / |Microwave irradiation 4: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine; bis(trichloromethyl) carbonate / dichloromethane / 18 h / 20 °C 5: QP-SA / dichloromethane / 20 h / 18 °C View Scheme
参考文献
Baxendale; Cheung; Kitching; Ley; Shearman
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4378 - 4387
反应条件
1: perchloric acid / water / 6 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine; bis(trichloromethyl) carbonate / dichloromethane / 18 h / 20 °C 3: QP-SA / dichloromethane / 20 h / 18 °C View Scheme
参考文献
Battilocchio, Claudio; Deadman, Benjamin J.; Nikbin, Nikzad; Kitching, Matthew O.; Baxendale, Ian R.; Ley, Steven V.
Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7917 - 7930
反应条件
1: methanol / 1 h / 160 °C 2: sodium ethanolate / ethanol / 0.42 h / 80 °C / |Microwave irradiation 3: N,N-dimethyl-formamide / 3 h / 140 °C / |Microwave irradiation 4: potassium hydroxide / water; tetrahydrofuran / 2 h / 120 °C / |Microwave irradiation 5: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine; bis(trichloromethyl) carbonate / dichloromethane / 18 h / 20 °C 6: QP-SA / dichloromethane / 20 h / 18 °C View Scheme
参考文献
Battilocchio, Claudio; Deadman, Benjamin J.; Nikbin, Nikzad; Kitching, Matthew O.; Baxendale, Ian R.; Ley, Steven V.
Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7917 - 7930
反应条件
1: ammonia; ammonium chloride / ethanol; water / 8 h / 55 °C / pH > 10 2: potassium carbonate / tetrahydrofuran; water / 1.5 h / 20 °C 3: hydrogenchloride; water / tetrahydrofuran / 18 h / 20 °C 4: hydrogenchloride / water; acetic acid / 72 h / |Reflux 5: tetrafluoroboric acid / water / 48 h / 60 °C / |Sealed tube 6: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C 7: trifluoroacetic acid / dichloromethane / 3.5 h / 35 °C View Scheme
参考文献
Baxendale; Cheung; Kitching; Ley; Shearman
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4378 - 4387
反应条件
1: hydrogenchloride / water; acetic acid / 72 h / |Reflux 2: tetrafluoroboric acid / water / 48 h / 60 °C / |Sealed tube 3: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C 4: trifluoroacetic acid / dichloromethane / 3.5 h / 35 °C View Scheme
参考文献
Baxendale; Cheung; Kitching; Ley; Shearman
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4378 - 4387
反应条件
1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C 2: trifluoroacetic acid / dichloromethane / 3.5 h / 35 °C View Scheme
参考文献
Baxendale; Cheung; Kitching; Ley; Shearman
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4378 - 4387
