Boc-γ-L-二高亮氨酸合成路线 （共 16 条）
反应条件
sodium hydroxide in water; acetone T=22°C; 0.5 h;
参考文献
Smrcina, Martin; Majer, Pavel; Majerova, Eva; Guerassina, Tatiana A.; Eissenstat, Michael A.
Tetrahedron, 1997 , vol. 53, # 38 p. 12867 - 12874
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; acetonitrile T=20°C; 24 h;
参考文献
Moutevelis-Minakakis, Panagiota; Sinanoglou, Charalambos; Loukas, Vassilios; Kokotos, George
Synthesis, 2005 , # 6 art. no. T08804ST, p. 933 - 938
反应条件
sodium hydroxide in 1,4-dioxane; water Ambient temperature; Yield given;
参考文献
Synthesis, , # 11 p. 1104 - 1108
反应条件
1: 85 percent / H2 / Pd/C / methanol / 20 °C 2: 62 percent / aq. NaIO4; RuCl3*3H2O / CCl4; acetonitrile / 24 h / 20 °C View Scheme
参考文献
Synthesis, , # 6 art. no. T08804ST, p. 933 - 938
反应条件
1.1: NMM / tetrahydrofuran / -10 °C 2.1: NaBH4 / methanol 3.1: aq. NaOCl; 4-acetamido-2,2,6,6-tetramethylpiperidine-1-yloxy; NaHCO3 / NaBr / ethyl acetate; toluene / 1 h / -5 °C 4.1: KHMDS / toluene / 0.25 h / 0 °C 4.2: 71 percent / toluene / 20 h / 20 °C 5.1: 85 percent / H2 / Pd/C / methanol / 20 °C 6.1: 62 percent / aq. NaIO4; RuCl3*3H2O / CCl4; acetonitrile / 24 h / 20 °C View Scheme
参考文献
Synthesis, , # 6 art. no. T08804ST, p. 933 - 938
反应条件
1.1: KHMDS / toluene / 0.25 h / 0 °C 1.2: 71 percent / toluene / 20 h / 20 °C 2.1: 85 percent / H2 / Pd/C / methanol / 20 °C 3.1: 62 percent / aq. NaIO4; RuCl3*3H2O / CCl4; acetonitrile / 24 h / 20 °C View Scheme
参考文献
Synthesis, , # 6 art. no. T08804ST, p. 933 - 938
反应条件
1.1: aq. NaOCl; 4-acetamido-2,2,6,6-tetramethylpiperidine-1-yloxy; NaHCO3 / NaBr / ethyl acetate; toluene / 1 h / -5 °C 2.1: KHMDS / toluene / 0.25 h / 0 °C 2.2: 71 percent / toluene / 20 h / 20 °C 3.1: 85 percent / H2 / Pd/C / methanol / 20 °C 4.1: 62 percent / aq. NaIO4; RuCl3*3H2O / CCl4; acetonitrile / 24 h / 20 °C View Scheme
参考文献
Synthesis, , # 6 art. no. T08804ST, p. 933 - 938
反应条件
1.1: NaBH4 / methanol 2.1: aq. NaOCl; 4-acetamido-2,2,6,6-tetramethylpiperidine-1-yloxy; NaHCO3 / NaBr / ethyl acetate; toluene / 1 h / -5 °C 3.1: KHMDS / toluene / 0.25 h / 0 °C 3.2: 71 percent / toluene / 20 h / 20 °C 4.1: 85 percent / H2 / Pd/C / methanol / 20 °C 5.1: 62 percent / aq. NaIO4; RuCl3*3H2O / CCl4; acetonitrile / 24 h / 20 °C View Scheme
参考文献
Synthesis, , # 6 art. no. T08804ST, p. 933 - 938
反应条件
1: 75 percent / toluene / 3 h / Heating 2: 73 percent / NaOH / acetone; H2O / 0.5 h / 22 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 38 p. 12867 - 12874
反应条件
1: NaBH4, AcOH / CH2Cl2 / 8 h / -5 °C 2: 75 percent / toluene / 3 h / Heating 3: 73 percent / NaOH / acetone; H2O / 0.5 h / 22 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 38 p. 12867 - 12874
