1: 98 percent / triethylamine; DMAP / CH2Cl2 / 1.5 h / 0 °C 2: 97 percent / TBAF / tetrahydrofuran / 3 h / 0 °C 3: 36 percent / Amberlyst 15 / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme

1: 97 percent / TBAF / tetrahydrofuran / 3 h / 0 °C 2: 36 percent / Amberlyst 15 / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme

1: 85 percent / HCl / methanol / 10 h / -20 °C 2: 98 percent / triethylamine; DMAP / CH2Cl2 / 1.5 h / 0 °C 3: 97 percent / TBAF / tetrahydrofuran / 3 h / 0 °C 4: 36 percent / Amberlyst 15 / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme

1: 91 percent / LiOH*H2O / methanol; H2O / 20 °C 2: 84 mg / N-ethylmorpholine; HBTU / acetonitrile / 18 h / 20 °C 3: 68 percent / LHMDS / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 4: 85 percent / HCl / methanol / 10 h / -20 °C 5: 98 percent / triethylamine; DMAP / CH2Cl2 / 1.5 h / 0 °C 6: 97 percent / TBAF / tetrahydrofuran / 3 h / 0 °C 7: 36 percent / Amberlyst 15 / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme

1: 84 percent / p-toluenesulfonic acid / dimethylformamide / 0.67 h / 60 °C 2: 95 percent / pyridine; Dess-Martin periodinane / CH2Cl2 / 18 h / 20 °C 3: 94 percent / pyridine / tetrahydrofuran; toluene / 0.33 h / -20 °C 4: 91 percent / diisobutylaluminum hydride / CH2Cl2; hexane / 3 h / -15 °C 5: 95 percent / triethylamine; DMAP / CH2Cl2 / 12 h / 20 °C 6: 92 percent / NaHCO3; DDQ / CH2Cl2; H2O / 8 h / 0 °C 7: 84 percent / NaHCO3; mCPBA / CH2Cl2 / 3 h / -15 - 0 °C 8: 70 percent / dimethylformamide / 48 h / 70 °C 9: 91 percent / diisobutylaluminum hydride / tetrahydrofuran; hexane / 2 h / -40 °C 10: 91 percent / molecular sieves 4 Angstroem; NMO; TPAP / CH2Cl2 / 3 h / 20 °C 11: 68 percent / LHMDS / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 12: 85 percent / HCl / methanol / 10 h / -20 °C 13: 98 percent / triethylamine; DMAP / CH2Cl2 / 1.5 h / 0 °C 14: 97 percent / TBAF / tetrahydrofuran / 3 h / 0 °C 15: 36 percent / Amberlyst 15 / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme

1: 84 mg / N-ethylmorpholine; HBTU / acetonitrile / 18 h / 20 °C 2: 68 percent / LHMDS / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 3: 85 percent / HCl / methanol / 10 h / -20 °C 4: 98 percent / triethylamine; DMAP / CH2Cl2 / 1.5 h / 0 °C 5: 97 percent / TBAF / tetrahydrofuran / 3 h / 0 °C 6: 36 percent / Amberlyst 15 / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme

1: 93 percent / benzene / 3 h / 60 °C 2: 99 percent / diisobutylaluminum hydride / toluene; hexane / 0.25 h / -68 - 0 °C 3: 96 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran; toluene / 3 h / 0 °C 4: 87 percent / (NH4)6Mo7O24*4H2O; H2O2 / ethanol / 2 h / 20 °C 5: HCl / ethyl acetate / 1.5 h / 20 °C 6: 84 mg / N-ethylmorpholine; HBTU / acetonitrile / 18 h / 20 °C 7: 68 percent / LHMDS / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 8: 85 percent / HCl / methanol / 10 h / -20 °C 9: 98 percent / triethylamine; DMAP / CH2Cl2 / 1.5 h / 0 °C 10: 97 percent / TBAF / tetrahydrofuran / 3 h / 0 °C 11: 36 percent / Amberlyst 15 / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme

1: 84 percent / NaHCO3; mCPBA / CH2Cl2 / 3 h / -15 - 0 °C 2: 70 percent / dimethylformamide / 48 h / 70 °C 3: 91 percent / diisobutylaluminum hydride / tetrahydrofuran; hexane / 2 h / -40 °C 4: 91 percent / molecular sieves 4 Angstroem; NMO; TPAP / CH2Cl2 / 3 h / 20 °C 5: 68 percent / LHMDS / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 6: 85 percent / HCl / methanol / 10 h / -20 °C 7: 98 percent / triethylamine; DMAP / CH2Cl2 / 1.5 h / 0 °C 8: 97 percent / TBAF / tetrahydrofuran / 3 h / 0 °C 9: 36 percent / Amberlyst 15 / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme

1: 94 percent / pyridine / tetrahydrofuran; toluene / 0.33 h / -20 °C 2: 91 percent / diisobutylaluminum hydride / CH2Cl2; hexane / 3 h / -15 °C 3: 95 percent / triethylamine; DMAP / CH2Cl2 / 12 h / 20 °C 4: 92 percent / NaHCO3; DDQ / CH2Cl2; H2O / 8 h / 0 °C 5: 84 percent / NaHCO3; mCPBA / CH2Cl2 / 3 h / -15 - 0 °C 6: 70 percent / dimethylformamide / 48 h / 70 °C 7: 91 percent / diisobutylaluminum hydride / tetrahydrofuran; hexane / 2 h / -40 °C 8: 91 percent / molecular sieves 4 Angstroem; NMO; TPAP / CH2Cl2 / 3 h / 20 °C 9: 68 percent / LHMDS / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 10: 85 percent / HCl / methanol / 10 h / -20 °C 11: 98 percent / triethylamine; DMAP / CH2Cl2 / 1.5 h / 0 °C 12: 97 percent / TBAF / tetrahydrofuran / 3 h / 0 °C 13: 36 percent / Amberlyst 15 / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme

1: 98 percent / diisobutylaluminum hydride / toluene; hexane / 0.5 h / -78 °C 2: 93 percent / benzene / 3 h / 60 °C 3: 99 percent / diisobutylaluminum hydride / toluene; hexane / 0.25 h / -68 - 0 °C 4: 96 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran; toluene / 3 h / 0 °C 5: 87 percent / (NH4)6Mo7O24*4H2O; H2O2 / ethanol / 2 h / 20 °C 6: HCl / ethyl acetate / 1.5 h / 20 °C 7: 84 mg / N-ethylmorpholine; HBTU / acetonitrile / 18 h / 20 °C 8: 68 percent / LHMDS / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 9: 85 percent / HCl / methanol / 10 h / -20 °C 10: 98 percent / triethylamine; DMAP / CH2Cl2 / 1.5 h / 0 °C 11: 97 percent / TBAF / tetrahydrofuran / 3 h / 0 °C 12: 36 percent / Amberlyst 15 / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme