S-2-n-boc-1,2-丙二胺合成路线 （共 9 条）
反应条件
hydrogen; palladium on activated charcoal in methanol 2 h;
参考文献
Kokotos, George; Constantinou-Kokotou, Violetta
Journal of Chemical Research, Miniprint, 1992 , # 12 p. 3117 - 3132
反应条件
1: With triethylamine in ethanol Heating / reflux; 2: With hydrogenchloride in water pH=3; 3: With sodium hydroxide in water
参考文献
ASTRAZENECA AB
Patent: WO2007/8144 A1, 2007 ;
Location in patent: Page/Page column 17; 23-24 ;
WO 2007/008144 A1
反应条件
1: 82 percent / triethylamine / CH2Cl2 / 1.) 0 deg C, 30 min, 2.) RT, 30 min 2: 89 percent / sodium azide / hexamethylphosphoric acid triamide / 6 h / 55 °C 3: 96 percent / hydrogen / 10percent palladium on charcoal / methanol / 2 h View Scheme
参考文献
Nishiwaki, Hisashi; Nagaoka, Hikaru; Kuriyama, Mituhiro; Yamauchi, Satoshi; Shuto, Yoshihiro
Bioscience, Biotechnology and Biochemistry, 2011 , vol. 75, # 4 p. 780 - 782
反应条件
1: 89 percent / sodium azide / hexamethylphosphoric acid triamide / 6 h / 55 °C 2: 96 percent / hydrogen / 10percent palladium on charcoal / methanol / 2 h View Scheme
参考文献
Medda, Amiya K.; Park, Chul Min; Jeon, Aram; Kim, Hyunwoo; Sohn, Jeong-Hun; Lee, Hee-Seung
Organic Letters, 2011 , vol. 13, # 13 p. 3486 - 3489
参考文献
Xu, Zhigang; DiCesare, John C.; Baures, Paul W.
Journal of Combinatorial Chemistry, 2010 , vol. 12, # 2 p. 248 - 254
反应条件
1: triethylamine / dichloromethane / 20 °C 2: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 20 °C 3: hydrazine hydrate / ethanol; dichloromethane / 20 °C View Scheme
参考文献
Hunt, Thomas; Atherton-Watson, Hazel C.; Collingwood, Stephen P.; Coote, Kevin J.; Czarnecki, Sarah; Danahay, Henry; Howsham, Catherine; Hunt, Peter; Paisley, Derek; Young, Alice
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2877 - 2879
反应条件
hydrogenchloride in tetrahydrofuran 30 h; Ambient temperature;
参考文献
Kokotos, George; Constantinou-Kokotou, Violetta
Journal of Chemical Research, Miniprint, 1992 , # 12 p. 3117 - 3132
反应条件
hydrogenchloride in tetrahydrofuran 30 h; Ambient temperature;
参考文献
Kokotos, George; Constantinou-Kokotou, Violetta
Journal of Chemical Research, Miniprint, 1992 , # 12 p. 3117 - 3132
反应条件
hydrogenchloride in tetrahydrofuran 30 h; Ambient temperature;
参考文献
Kokotos, George; Constantinou-Kokotou, Violetta
Journal of Chemical Research, Miniprint, 1992 , # 12 p. 3117 - 3132
