(R)-1-(甲氧基(甲基)氨基)-1-氧代-2-丙基氨基甲酸叔丁酯合成路线 （共 16 条）
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Valverde, Ibai E.; Bauman, Andreas; Kluba, Christiane A.; Vomstein, Sandra; Walter, Martin A.; Mindt, Thomas L.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 34 p. 8957 - 8960
Angew. Chem., 2013 , vol. 125, # 34 p. 9126 - 9129,4
反应条件
dicyclohexyl-carbodiimide in chloroform
参考文献
Zhou, Zheng Hong; Tang, Yi Long; Li, Kang Ying; Liu, Bing; Tang, Chu Chi
Heteroatom Chemistry, 2003 , vol. 14, # 7 p. 603 - 606
反应条件
isopropylmagnesium chloride in tetrahydrofuran T=-20°C; 1.5 h;
参考文献
VALORISATION-RECHERCHE, societe en commandite
Patent: WO2005/97812 A1, 2005 ;
Location in patent: Page/Page column 50 ;
反应条件
COMUreg;; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=0 - 20°C; 2.83333 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Tyrrell, Elizabeth; Brawn, Peter; Carew, Mark; Greenwood, Iain
Tetrahedron Letters, 2011 , vol. 52, # 3 p. 369 - 372
反应条件
1: CH2Cl2 / 0.5 h / 0 °C 2: Et3N / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576
反应条件
triethylamine in dichloromethane 4 h; Ambient temperature; Yield given;
参考文献
Patel, Bhavesh H.; Mason, Andrew M.; Patel, Hetal; Coombes, R. Charles; Ali, Simak; Barrett, Anthony G. M.
Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 6209 - 6217
反应条件
in dichloromethane T=0 - 20°C; 6.25 h;
参考文献
White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576
反应条件
1: 75 percent / aq. NaOH / 2-methyl-propan-2-ol / 12 h / Ambient temperature 2: N-methylpiperidine / CH2Cl2 / 0.25 h / -25 °C 3: CH2Cl2 / 3 h / -25 - 20 °C View Scheme
参考文献
Lucet, Denis; Le Gall, Thierry; Mioskowski, Charles; Ploux, Olivier; Marquet, Andree
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 985 - 988
反应条件
in dichloromethane T=-25 - 20°C; 3 h; Yield given;
参考文献
Lucet, Denis; Le Gall, Thierry; Mioskowski, Charles; Ploux, Olivier; Marquet, Andree
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 985 - 988
反应条件
sodium hydrogensulfite in chloroform 1 h;
参考文献
Iorga, Bogdan; Campagne, Jean-Marc
Synlett, 2004 , # 10 p. 1826 - 1828
