1: 73 percent / TFA, t-BuI, I2, FeCl2 / dimethylsulfoxide / 5 h / 80 - 85 °C 2: 93 percent / HCl / diethyl ether / 65 h / Heating 3: 86 percent / NiCl2, BaBH4 / methanol / 0.08 h / 50 °C 4: 64 percent / aq. HCl / tetrahydrofuran / 1 h / 40 °C 5: CH2Cl2 / 15 h / Ambient temperature 6: 1.) NaH / 1.) THF, room temperature 45 min, reflux - 15 min, 2.) THF, 14 h 7: 80 percent / TFA / CH2Cl2 / 1.5 h / Ambient temperature 8: 60 percent / ceric ammonium nitrate 9: 98 percent / NH4Cl View Scheme

1: 1.) AcOH, FeCl3, 2.) AcOH / 1.) 60 deg C, 5 min, 2.) reflux, 5 h 2: 63 percent / HNO3 / 1.) -50-(-40) deg C, 1 h, 2.) -30 deg C, 25 min 3: 73 percent / TFA, t-BuI, I2, FeCl2 / dimethylsulfoxide / 5 h / 80 - 85 °C 4: 93 percent / HCl / diethyl ether / 65 h / Heating 5: 86 percent / NiCl2, BaBH4 / methanol / 0.08 h / 50 °C 6: 64 percent / aq. HCl / tetrahydrofuran / 1 h / 40 °C 7: CH2Cl2 / 15 h / Ambient temperature 8: 1.) NaH / 1.) THF, room temperature 45 min, reflux - 15 min, 2.) THF, 14 h 9: 80 percent / TFA / CH2Cl2 / 1.5 h / Ambient temperature 10: 60 percent / ceric ammonium nitrate 11: 98 percent / NH4Cl View Scheme

1: CH2Cl2 / 15 h / Ambient temperature 2: 1.) NaH / 1.) THF, room temperature 45 min, reflux - 15 min, 2.) THF, 14 h 3: 80 percent / TFA / CH2Cl2 / 1.5 h / Ambient temperature 4: 60 percent / ceric ammonium nitrate 5: 98 percent / NH4Cl View Scheme

1: 64 percent / aq. HCl / tetrahydrofuran / 1 h / 40 °C 2: CH2Cl2 / 15 h / Ambient temperature 3: 1.) NaH / 1.) THF, room temperature 45 min, reflux - 15 min, 2.) THF, 14 h 4: 80 percent / TFA / CH2Cl2 / 1.5 h / Ambient temperature 5: 60 percent / ceric ammonium nitrate 6: 98 percent / NH4Cl View Scheme

1: 80 percent / TFA / CH2Cl2 / 1.5 h / Ambient temperature 2: 60 percent / ceric ammonium nitrate 3: 98 percent / NH4Cl View Scheme

1: 1.) NaH / 1.) THF, room temperature 45 min, reflux - 15 min, 2.) THF, 14 h 2: 80 percent / TFA / CH2Cl2 / 1.5 h / Ambient temperature 3: 60 percent / ceric ammonium nitrate 4: 98 percent / NH4Cl View Scheme

1: 1.) BH3*SMe2; 2.) CAN / 1.) THF, r.t., 3 h; 2.) 60percent aq. CH3CN, 0 deg C, 5 min 2: 98 percent / NH4Cl / methanol / Ambient temperature View Scheme

1: sodium iodide / acetone / 5 h / |Inert atmosphere; |Reflux 2: n-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / 0.5 h / -78 - 0 °C / |Inert atmosphere; |Schlenk technique 3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 0.33 h / 0 °C / |Inert atmosphere 4: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / |Inert atmosphere 5: water; sodium hydroxide / methanol / 0.5 h / |Reflux; |Inert atmosphere 6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere 7: salenCo(II); oxygen / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere 8: ammonium chloride / methanol / 13 h / 20 °C / |Inert atmosphere View Scheme

1: n-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / 0.5 h / -78 - 0 °C / |Inert atmosphere; |Schlenk technique 2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 0.33 h / 0 °C / |Inert atmosphere 3: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / |Inert atmosphere 4: water; sodium hydroxide / methanol / 0.5 h / |Reflux; |Inert atmosphere 5: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere 6: salenCo(II); oxygen / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere 7: ammonium chloride / methanol / 13 h / 20 °C / |Inert atmosphere View Scheme

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 0.33 h / 0 °C / |Inert atmosphere 2: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / |Inert atmosphere 3: water; sodium hydroxide / methanol / 0.5 h / |Reflux; |Inert atmosphere 4: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere 5: salenCo(II); oxygen / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere 6: ammonium chloride / methanol / 13 h / 20 °C / |Inert atmosphere View Scheme