1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / |Inert atmosphere 2: water; sodium hydroxide / methanol / 0.5 h / |Reflux; |Inert atmosphere 3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere 4: salenCo(II); oxygen / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere 5: ammonium chloride / methanol / 13 h / 20 °C / |Inert atmosphere View Scheme

1: water; sodium hydroxide / methanol / 0.5 h / |Reflux; |Inert atmosphere 2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere 3: salenCo(II); oxygen / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere 4: ammonium chloride / methanol / 13 h / 20 °C / |Inert atmosphere View Scheme

1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere 2: salenCo(II); oxygen / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere 3: ammonium chloride / methanol / 13 h / 20 °C / |Inert atmosphere View Scheme

1: acetonitrile / 4 h / |Reflux; |Inert atmosphere 2: AlCl3, aluminium chloride; lithium aluminium tetrahydride / diethyl ether / 0.33 h / 0 °C / |Inert atmosphere 3: triethylamine / 1,2-dichloro-ethane / 10 h / 20 °C / |Inert atmosphere 4: sodium iodide / acetone / 5 h / |Inert atmosphere; |Reflux 5: n-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / 0.5 h / -78 - 0 °C / |Inert atmosphere; |Schlenk technique 6: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 0.33 h / 0 °C / |Inert atmosphere 7: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / |Inert atmosphere 8: water; sodium hydroxide / methanol / 0.5 h / |Reflux; |Inert atmosphere 9: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere 10: salenCo(II); oxygen / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere 11: ammonium chloride / methanol / 13 h / 20 °C / |Inert atmosphere View Scheme

1: 96 percent / aq. acetic acid / 15 h / Ambient temperature 2: 97 percent / NaH / tetrahydrofuran / 0 °C 3: 1.) t-BuLi, 2.) Cl3CCCl3 / 1.) ether, pentane, -78 deg C, 20 min, 0 deg C, 1 h, 2.) ether, pentane, -78 deg C to rt 4: benzene / Ambient temperature 5: 3.46 g / TBAF / tetrahydrofuran / 1 h 6: 99 percent / NaH / tetrahydrofuran / 0.5 h / 0 °C 7: 52 percent / BH3*THF / tetrahydrofuran / 16 h / Ambient temperature; other solvent, reagent, temperature, reaction time 8: 54 percent / LDA / tetrahydrofuran / -50 - 0 °C / other reagent, temperature, reaction time 9: O2, salcomine / dimethylformamide / 2 h / Ambient temperature 10: NH4Cl / methanol / 13 h / Ambient temperature View Scheme

1: 97 percent / NaH / tetrahydrofuran / 0 °C 2: 1.) t-BuLi, 2.) Cl3CCCl3 / 1.) ether, pentane, -78 deg C, 20 min, 0 deg C, 1 h, 2.) ether, pentane, -78 deg C to rt 3: benzene / Ambient temperature 4: 3.46 g / TBAF / tetrahydrofuran / 1 h 5: 99 percent / NaH / tetrahydrofuran / 0.5 h / 0 °C 6: 52 percent / BH3*THF / tetrahydrofuran / 16 h / Ambient temperature; other solvent, reagent, temperature, reaction time 7: 54 percent / LDA / tetrahydrofuran / -50 - 0 °C / other reagent, temperature, reaction time 8: O2, salcomine / dimethylformamide / 2 h / Ambient temperature 9: NH4Cl / methanol / 13 h / Ambient temperature View Scheme

1: 54 percent / LDA / tetrahydrofuran / -50 - 0 °C / other reagent, temperature, reaction time 2: O2, salcomine / dimethylformamide / 2 h / Ambient temperature 3: NH4Cl / methanol / 13 h / Ambient temperature View Scheme

1: 52 percent / BH3*THF / tetrahydrofuran / 16 h / Ambient temperature; other solvent, reagent, temperature, reaction time 2: 54 percent / LDA / tetrahydrofuran / -50 - 0 °C / other reagent, temperature, reaction time 3: O2, salcomine / dimethylformamide / 2 h / Ambient temperature 4: NH4Cl / methanol / 13 h / Ambient temperature View Scheme

1: DCC / tetrahydrofuran / -15 deg C, 1.5 h then to r.t., overnight 2: 1.) BH3*SMe2; 2.) CAN / 1.) THF, r.t., 3 h; 2.) 60percent aq. CH3CN, 0 deg C, 5 min 3: 98 percent / NH4Cl / methanol / Ambient temperature View Scheme

1: 10M KOH / ethanol / 0.5 h / Ambient temperature 2: DCC / tetrahydrofuran / -15 deg C, 1.5 h then to r.t., overnight 3: 1.) BH3*SMe2; 2.) CAN / 1.) THF, r.t., 3 h; 2.) 60percent aq. CH3CN, 0 deg C, 5 min 4: 98 percent / NH4Cl / methanol / Ambient temperature View Scheme