2-羟基-N,N-二甲基乙酰胺合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate P=760 Torr; 24 h;
参考文献
Haberman, Jannine M.; Gin, David Y.
Organic Letters, 2003 , vol. 5, # 14 p. 2539 - 2541
反应条件
in water T=20°C; 16 h;
参考文献
JANSSEN RandD IRELAND; BONFANTI, Jean-François; FORTIN, Jérôme Michel Claude; MULLER, Philippe; DOUBLET, Frédéric Marc Maurice; RABOISSON, Pierre Jean-Marie Bernard; ARNOULT, Eric Pierre Alexandre
Patent: WO2014/9509 A1, 2014 ;
Location in patent: Page/Page column 21; 22 ;
反应条件
hydrogen; Cu/Al2O3/SiO2 in tetrahydrofuran T=170°C; P=41254.1 Torr; 18 h; Autoclave; Product distribution / selectivity;
参考文献
WO2010/130696 A1, ;
Page/Page column 10-12 ;
反应条件
dimethyl amine in water; ethyl acetate
参考文献
US5250542 A1, ;
US 5250542 A
反应条件
in tetrahydrofuran T=0 - 20°C; 4 h; Yield given;
参考文献
Journal of the American Chemical Society, , vol. 115, # 21 p. 9774 - 9788
参考文献
Blum, Zoltan; Nyberg, Klas
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 3 p. 165 - 170
反应条件
potassium hydroxide in ethanol 1 h; Ambient temperature;
参考文献
Nielsen; Bundgaard
Journal of pharmaceutical sciences, 1988 , vol. 77, # 4 p. 285 - 298
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 18, p. 141 - 149
参考文献
Journal of Organic Chemistry, , vol. 15, p. 317,323
反应条件
Tris-HCl buffer; human liver carboxylesterase pI 5.3 T=37°C; Hydrolysis; pH=7.4; Enzyme kinetics;
参考文献
Biological and Pharmaceutical Bulletin, , vol. 20, # 8 p. 869 - 873
