1-Boc-4-烯丙基-4-哌啶甲酸乙酯合成路线 （共 12 条）
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 0.5 h; Cooling with ice;
参考文献
US2012/88750 A1, ;
Page/Page column 35 ;
反应条件
1.1: O3 / methanol; CH2Cl2 / -78 °C
1.2: NaBH4 / 3 h / -78 - 20 °C
2.1: p-TsOH / toluene / 3 h / Heating
3.1: DIBAL-H / CH2Cl2 / 5 h / -78 - 0 °C
4.1: PPh3; diethyl azodicarboxylate / tetrahydrofuran / 16 h / 0 - 20 °C
View Scheme
参考文献
Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762
