N-Boc-1,2-亚苯基二胺合成路线 (共 20 条)
反应条件
[TMGH][OAc] T=20°C; 0.1 h; Neat (no solvent);
参考文献
Akbari, Jafar; Heydari, Akbar; Ma'mani, Leila; Hassan Hosseini, Seyed
Comptes Rendus Chimie, 2010 , vol. 13, # 5 p. 544 - 547
反应条件
anhydrous iron chloride; hydrazine hydrate in methanol T=90°C; 3 h;
参考文献
MASSACHUSETTS INSTITUTE OF TECHNOLOGY; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; THE BROAD INSTITUTE, INC.; TSAI, Li-Huei; GUAN, Ji-Song; HAGGARTY, Stephen, J.; HOLSON, Edward; WAGNER, Florence; GRAEFF, Johannes
Patent: WO2011/53876 A1, 2011 ;
Location in patent: Page/Page column 50 - 51 ;
反应条件
triethylamine in N,N-dimethyl-formamide T=55°C; 12 h;
参考文献
GENENTECH, INC.
Patent: WO2007/120339 A1, 2007 ;
Location in patent: Page/Page column 40 ;
WO 2007/120339 A1
反应条件
triethylamine in N,N-dimethyl-formamide T=55°C; 12 h;
参考文献
GENENTECH, INC.
Patent: WO2008/79719 A1, 2008 ;
Location in patent: Page/Page column 43-44 ;
WO 2008/079719 A1
反应条件
triethylamine in N,N-dimethyl-formamide T=55°C; 3 h;
参考文献
Seto, Christopher T.; Mathias, John P.; Whitesides, George M.
Journal of the American Chemical Society, 1993 , vol. 115, # 4 p. 1321 - 1329
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Mitsui Chemicals, Inc.
Patent: US6174905 B1, 2001 ;
参考文献
Letters in Organic Chemistry, , vol. 8, # 1 p. 38 - 42
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere 1.2: 5 h / 23 °C 2.1: hydrazine hydrate; anhydrous iron chloride / methanol / 90 °C View Scheme
反应条件
in N,N-dimethyl-formamide T=55°C; 3 h;
参考文献
Isfort, Christian Schulze; Kreickmann, Thorsten; Pape, Tania; Froehlich, Roland; Hahn, F. Ekkehardt
Chemistry - A European Journal, 2007 , vol. 13, # 8 p. 2344 - 2357
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere 1.2: 5 h / 23 °C 2.1: hydrazine hydrate; anhydrous iron chloride / methanol / 90 °C View Scheme