N-Boc-1,2-亚苯基二胺合成路线 （共 20 条）
反应条件
1.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane 2.1: potassium carbonate; dihydroxyborane / 1,4-dioxane; water / 0.5 h / |Inert atmosphere 2.2: 20 h / 90 °C / |Inert atmosphere 3.1: palladium 10 on activated carbon; hydrogen / ethyl acetate / |Inert atmosphere View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 5, # 4 p. 340 - 345
反应条件
1.1: potassium carbonate; dihydroxyborane / 1,4-dioxane; water / 0.5 h / |Inert atmosphere 1.2: 20 h / 90 °C / |Inert atmosphere 2.1: palladium 10 on activated carbon; hydrogen / ethyl acetate / |Inert atmosphere View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 5, # 4 p. 340 - 345
反应条件
1: in hexafluoroisopropyl alcohol T=30°C; Diels-Alder reaction; 2: With hydrogenchloride; oxygen in water; acetonitrile P=760.051 Torr; 16 h;
参考文献
De, Kavita; Legros, Julien; Crousse, Benoit; Chandrasekaran, Srinivasan; Bonnet-Delpon, Daniele
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 2 p. 347 - 350
反应条件
1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; pyridine / 48 h / 23 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 23 °C 2.2: pH ~ 8 View Scheme
参考文献
MASSACHUSETTS INSTITUTE OF TECHNOLOGY; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; THE BROAD INSTITUTE, INC.; TSAI, Li-Huei; GUAN, Ji-Song; HAGGARTY, Stephen, J.; HOLSON, Edward; WAGNER, Florence; GRAEFF, Johannes
Patent: WO2011/53876 A1, 2011 ;
反应条件
1: 100 percent / N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide; 1-hydroxyazabenzotriazole / dimethylformamide
2: 100 percent / TFA / CH2Cl2
View Scheme
参考文献
Sessler, Jonathan L.; Katayev, Evgeny; Dan Pantos; Scherbakov, Pavel; Reshetova, Marina D.; Khrustalev, Victor N.; Lynch, Vincent M.; Ustynyuk, Yuri A.
Journal of the American Chemical Society, 2005 , vol. 127, # 32 p. 11442 - 11446
反应条件
1: With ytterbium(III) triflate in acetonitrile
0.25 h;
2: With hydrogenchloride; oxygen in water; acetonitrile
P=760.051 Torr; 16 h;
参考文献
De, Kavita; Legros, Julien; Crousse, Benoit; Chandrasekaran, Srinivasan; Bonnet-Delpon, Daniele
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 2 p. 347 - 350
反应条件
1.1: 91 percent / triethylamine / toluene / 12 h / Heating
2.1: sodium borohydride / methanol / 0.08 h / -5 - 0 °C
2.2: 85 percent / hydrochloric acid / methanol; ethanol / -5 - 0 °C
3.1: 73 percent / CF3COOH; air / CH2Cl2 / 4 h / 20 °C
View Scheme
参考文献
Cul, Armelle; Daich, Adam; Decroix, Bernard; Sanz, Gerard; Van Hijfte, Luc
Tetrahedron, 2004 , vol. 60, # 48 p. 11029 - 11039
反应条件
1: neat (no solvent) / 0.25 h / 20 °C
2: trifluoroacetic acid; [bis(acetoxy)iodo]benzene / N,N-dimethyl-formamide / 24 h / 20 °C / |Inert atmosphere; |Darkness
3: sodium hydroxide / water / 12 h / |Reflux
View Scheme
参考文献
Okumura, Sota; Takeda, Youhei; Kiyokawa, Kensuke; Minakata, Satoshi
Chemical Communications, 2013 , vol. 49, # 81 p. 9266 - 9268
反应条件
1: neat (no solvent) / 0.25 h / 20 °C
2: trifluoroacetic acid; [bis(acetoxy)iodo]benzene / N,N-dimethyl-formamide / 24 h / 20 °C / |Inert atmosphere; |Darkness
3: sodium hydroxide / water / 12 h / |Reflux
4: acetic anhydride / 3 h / |Reflux
View Scheme
参考文献
Okumura, Sota; Takeda, Youhei; Kiyokawa, Kensuke; Minakata, Satoshi
Chemical Communications, 2013 , vol. 49, # 81 p. 9266 - 9268
反应条件
1: neat (no solvent) / 0.25 h / 20 °C
2: trifluoroacetic acid; [bis(acetoxy)iodo]benzene / N,N-dimethyl-formamide / 24 h / 20 °C / |Inert atmosphere; |Darkness
View Scheme
参考文献
Okumura, Sota; Takeda, Youhei; Kiyokawa, Kensuke; Minakata, Satoshi
Chemical Communications, 2013 , vol. 49, # 81 p. 9266 - 9268
