2-乙酰氨基-3-(4-氰基苯基)-丙酸合成路线 （共 8 条）
反应条件
1: KI, NaOEt / dioxane / Heating 2: aq. NaOH / Heating View Scheme
参考文献
Pearson, Daniel A.; Lister-James, John; McBride, William J.; Wilson, David M.; Martel, Lawrence J.; Civitello, Edgar R.; Dean, Richard T.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1372 - 1382
反应条件
hydrogenchloride; sodium hydroxide 1.) EtOH, reflux, 18 h, 2.) EtOH; Yield given. Multistep reaction;
参考文献
Kim, Sangsoo; Hwang, Sang Yeul; Kim, Young Kwan; Yun, Mikyung; Oh, Yeong Soo
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 7 p. 769 - 774
反应条件
1.1: NBS; benzoylperoxide / CCl4 / Heating 2.1: KI; NaOEt / dioxane / Heating 2.2: aq. NaOH / Heating View Scheme
参考文献
Lee, Koo; Jung, Won-Hyuk; Sang, Yeul Hwang; Lee, Sung-Hack
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2483 - 2486
反应条件
1: With sodium ethanolate; potassium iodide in 1,4-dioxane Condensation; Heating; 2: With sodium hydroxide Hydrolysis; decarboxylation; Heating;
参考文献
Lee, Koo; Jung, Won-Hyuk; Sang, Yeul Hwang; Lee, Sung-Hack
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2483 - 2486
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Kim, Sangsoo; Hwang, Sang Yeul; Kim, Young Kwan; Yun, Mikyung; Oh, Yeong Soo
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 7 p. 769 - 774
反应条件
1: acylase / H2O / 36 °C / pH 6.5 2: dioxane View Scheme
参考文献
Lee, Koo; Jung, Won-Hyuk; Sang, Yeul Hwang; Lee, Sung-Hack
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2483 - 2486
反应条件
lithium hydroxide 56 h; porcine kidney acylase, pH 7.2-7.5;
参考文献
Pearson, Daniel A.; Lister-James, John; McBride, William J.; Wilson, David M.; Martel, Lawrence J.; Civitello, Edgar R.; Dean, Richard T.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1372 - 1382
反应条件
1: 70.7 percent / aq. LiOH / 56 h / porcine kidney acylase, pH 7.2-7.5 2: 89 percent / aq. Na2CO3 / dioxane / 1.5 h / 0 - 20 °C View Scheme
参考文献
Pearson, Daniel A.; Lister-James, John; McBride, William J.; Wilson, David M.; Martel, Lawrence J.; Civitello, Edgar R.; Dean, Richard T.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1372 - 1382
