(R)-2-乙酰基氨基-3-(4-氰基苯基)-丙酸合成路线 （共 4 条）
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; hydrogen; (2S,4S)-4-(diphenylphosphino)-2-[(diphenylphosphino)methyl]-1-(tert-butoxycarbonyl)pyrrolidine; triethylamine in methanol; toluene T=10 - 15°C; P=7500.6 Torr; 20 h;
参考文献
Jendralla, Heiner; Seuring, Bernhard; Herchen, Joerg; Kulitzscher, Bernd; Wunner, Joachim; et al.
Tetrahedron, 1995 , vol. 51, # 44 p. 12047 - 12068
反应条件
1: 96 percent / NaOH / H2O / 3.5 h / 80 - 90 °C / pH </= 9 2: 91 percent / NEt3, H2, (-)-BPPM, <Rh(COD)Cl>2 / methanol; toluene / 20 h / 10 - 15 °C / 7500.6 Torr View Scheme
参考文献
Jendralla, Heiner; Seuring, Bernhard; Herchen, Joerg; Kulitzscher, Bernd; Wunner, Joachim; et al.
Tetrahedron, 1995 , vol. 51, # 44 p. 12047 - 12068
反应条件
1: 74 percent / NaOAc, Ac2O / acetone / 1 h / Heating 2: 96 percent / NaOH / H2O / 3.5 h / 80 - 90 °C / pH </= 9 3: 91 percent / NEt3, H2, (-)-BPPM, <Rh(COD)Cl>2 / methanol; toluene / 20 h / 10 - 15 °C / 7500.6 Torr View Scheme
参考文献
Jendralla, Heiner; Seuring, Bernhard; Herchen, Joerg; Kulitzscher, Bernd; Wunner, Joachim; et al.
Tetrahedron, 1995 , vol. 51, # 44 p. 12047 - 12068
反应条件
hydrogenchloride in water Heating;
参考文献
Jendralla, Heiner; Seuring, Bernhard; Herchen, Joerg; Kulitzscher, Bernd; Wunner, Joachim; et al.
Tetrahedron, 1995 , vol. 51, # 44 p. 12047 - 12068
