(4S)-4-乙基-4-羟基-1H-吡喃并[3,4-c]吡啶-3,8(4h,7h)-二酮合成路线 （共 48 条）
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 2: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 3: hydrogen bromide / water / 2 h / Reflux View Scheme
参考文献
Yu, Shanbao; Huang, Qing-Qing; Luo, Yu; Lu, Wei
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 713 - 717
反应条件
1.1: t-BuOK / 1,2-dimethoxy-ethane / 0.5 h / 20 °C 1.2: 81 percent / 1,2-dimethoxy-ethane / 12 h / Heating 2.1: 64 percent / (PPh3)2Pd(OAc)2; KOAc / acetonitrile / 12 h / 100 °C View Scheme
参考文献
Comins; Baevsky; Hong
Journal of the American Chemical Society, 1992 , vol. 114, # 27 p. 10971 - 10972
反应条件
1.1: potassium tert-butylate / ethylene glycol dimethyl ether / 0.5 h / 20 °C 1.2: 12 h / Reflux 2.1: bis(acetato)bis(triphenylphosphine)palladium(0); potassium acetate / acetonitrile / 12 h / 100 °C / Inert atmosphere View Scheme
参考文献
Zhao, Lei; Xiong, Fang-Jun; Chen, Wen-Xue; Chen, Fen-Er
Synthesis, 2011 , # 24 art. no. F87011SS, p. 4045 - 4049
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 2: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Yu, Shanbao; Huang, Qing-Qing; Luo, Yu; Lu, Wei
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 713 - 717
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 2: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 3: hydrogen bromide / water / 2 h / Reflux View Scheme
参考文献
Yu, Shanbao; Huang, Qing-Qing; Luo, Yu; Lu, Wei
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 713 - 717
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 2: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Yu, Shanbao; Huang, Qing-Qing; Luo, Yu; Lu, Wei
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 713 - 717
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 2: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 3: hydrogen bromide / water / 2 h / Reflux View Scheme
参考文献
Yu, Shanbao; Huang, Qing-Qing; Luo, Yu; Lu, Wei
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 713 - 717
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in methanol
参考文献
Comins, Daniel L.; Hong, Hao; Jianhua, Gao
Tetrahedron Letters, 1994 , vol. 35, # 30 p. 5331 - 5334
反应条件
1: 1.) t-BuLi, 3.) n-BuLi, 4.) I2
2: 92 percent / Et3SIH, TFA
3: 1.) n-BuLi
4: 76 percent / 2 N aq. NaOH / ethanol
5: 1.) TMSCl, NaI, Dabco, 2.) 6 N aq. HCl / 1.) CH3CN, reflux, 5 h, 2.) 100 deg C, 4 h
6: 95 percent / H2, NaOAc / Pd/C / methanol
View Scheme
参考文献
Comins; Baevsky; Hong
Journal of the American Chemical Society, 1992 , vol. 114, # 27 p. 10971 - 10972
反应条件
1: 92 percent / Et3SIH, TFA
2: 1.) n-BuLi
3: 76 percent / 2 N aq. NaOH / ethanol
4: 1.) TMSCl, NaI, Dabco, 2.) 6 N aq. HCl / 1.) CH3CN, reflux, 5 h, 2.) 100 deg C, 4 h
5: 95 percent / H2, NaOAc / Pd/C / methanol
View Scheme
参考文献
Comins; Baevsky; Hong
Journal of the American Chemical Society, 1992 , vol. 114, # 27 p. 10971 - 10972
