(4S)-4-乙基-4-羟基-1H-吡喃并[3,4-c]吡啶-3,8(4h,7h)-二酮合成路线 （共 48 条）
反应条件
1: 63 percent / n-BuLi / tetrahydrofuran / 0.02 h / -100 °C
2: 75 percent / 10percent HCl / methanol; H2O / 36 h / Heating
3: 95 percent / H2 / Pd/C
View Scheme
参考文献
Comins, Daniel L.; Hong, Hao; Jianhua, Gao
Tetrahedron Letters, 1994 , vol. 35, # 30 p. 5331 - 5334
反应条件
1: 65 percent / BF3*OEt2 / CH2Cl2
2: 63 percent / n-BuLi / tetrahydrofuran / 0.02 h / -100 °C
3: 75 percent / 10percent HCl / methanol; H2O / 36 h / Heating
4: 95 percent / H2 / Pd/C
View Scheme
参考文献
Comins, Daniel L.; Hong, Hao; Jianhua, Gao
Tetrahedron Letters, 1994 , vol. 35, # 30 p. 5331 - 5334
反应条件
1: 66 percent / cerium(III) chloride; NaBH4 / ethanol / 2 h / 20 °C
2: conc. HCl / 1,2-dimethoxy-ethane / 4 h
View Scheme
参考文献
Peters, Rene; Althaus, Martin; Nagy, Anne-Laure
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 3 p. 498 - 509
反应条件
1: 90 percent / dimethylformamide / 17 h / 20 °C
2: ammonium acetate / dimethylformamide / 19 h / 80 °C
3: 66 percent / cerium(III) chloride; NaBH4 / ethanol / 2 h / 20 °C
4: conc. HCl / 1,2-dimethoxy-ethane / 4 h
View Scheme
参考文献
Peters, Rene; Althaus, Martin; Nagy, Anne-Laure
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 3 p. 498 - 509
反应条件
1: ammonium acetate / dimethylformamide / 19 h / 80 °C
2: 66 percent / cerium(III) chloride; NaBH4 / ethanol / 2 h / 20 °C
3: conc. HCl / 1,2-dimethoxy-ethane / 4 h
View Scheme
参考文献
Peters, Rene; Althaus, Martin; Nagy, Anne-Laure
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 3 p. 498 - 509
反应条件
1: Cs2CO3 / ethanol
2: 90 percent / dimethylformamide / 17 h / 20 °C
3: ammonium acetate / dimethylformamide / 19 h / 80 °C
4: 66 percent / cerium(III) chloride; NaBH4 / ethanol / 2 h / 20 °C
5: conc. HCl / 1,2-dimethoxy-ethane / 4 h
View Scheme
参考文献
Peters, Rene; Althaus, Martin; Nagy, Anne-Laure
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 3 p. 498 - 509
参考文献
Comins, Daniel L.; Saha, Jayanta K.
Tetrahedron Letters, 1995 , vol. 36, # 44 p. 7995 - 7998
反应条件
hydrogenchloride in ethylene glycol dimethyl ether
4 h;
参考文献
Peters, Rene; Althaus, Martin; Nagy, Anne-Laure
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 3 p. 498 - 509
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C
2: 74 percent / NBS, DBP / CCl4
3: 96 percent / butan-2-one / 0.25 h / Heating
4: NaOH / H2O
5: 3N HCl / 21 h / Heating
View Scheme
参考文献
Comins, Daniel L.; Saha, Jayanta K.
Tetrahedron Letters, 1995 , vol. 36, # 44 p. 7995 - 7998
反应条件
1: 88 percent / i-Pr2NEt, DMAP / CH2Cl2 / Ambient temperature
2: 1.) n-BuLi / 1.) THF, -78 deg C
3: 39 percent / 3N HCl
View Scheme
参考文献
Comins, Daniel L.; Saha, Jayanta K.
Tetrahedron Letters, 1995 , vol. 36, # 44 p. 7995 - 7998
