6-甲基苯并[b]噻吩-2-羧酸合成路线 （共 6 条）
反应条件
hydrogenchloride; NaOH; ammonium formate; palladium monocarbide in methanol; water; ethyl acetate
参考文献
MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A.
Patent: US2012/65370 A1, 2012 ;
反应条件
1: With hydrogen; sodium hydroxide; 5 Pd(II)/C(eggshell) in tetrahydrofuran; methanol T=20°C; Inert atmosphere; 2: With hydrogenchloride in water; ethyl acetate Product distribution / selectivity;
参考文献
MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A.; BONACCORSI, Fabrizio; FEDI, Valentina; GIANNOTTI, Danilo
Patent: WO2010/133306 A1, 2010 ;
Location in patent: Page/Page column 9; 24; 25 ;
反应条件
hydrogenchloride; NaOH in tetrahydrofuran; methanol; ethyl acetate
参考文献
MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A.
Patent: US2012/65370 A1, 2012 ;
反应条件
iodine in 1,4-dioxane T=180°C; 0.133333 h; microwave irradiation;
参考文献
Allen, Daniel; Callaghan, Owen; Cordier, Frederic L.; Dobson, David R.; Harris, John R.; Hotten, Terry M.; Owton, W. Martin; Rathmell, Richard E.; Wood, Virginia A.
Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9645 - 9647
反应条件
hydrogenchloride
3 h; Heating;
参考文献
Cross; Dickinson; Parry; Randall
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1637 - 1643
反应条件
1: lithium aluminum hydride / diethyl ether / 3 h / Heating
2: chromium trioxide-pyridine complex / pyridine / 2 h / Ambient temperature
View Scheme
参考文献
Tominaga, Yoshinori; Pratap, Ram; Castle, Raymond N.; Lee, Milton L.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 871 - 877
