(1R,2S,3S,5S)-3-(3,4-二氯苯基)-8-氮杂双环[3.2.1]辛烷-2-羧酸甲酯合成路线 （共 7 条）
反应条件
1: With 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane 2: With methanol
参考文献
Newman, Amy Hauck; Zou, Mu-Fa; Ferrer, Jasmine V.; Javitch, Jonathan A.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 13 p. 1659 - 1661
反应条件
1: POCl3 / Heating 2: 168 h / Ambient temperature 3: 2.) trifluoroacetic acid / 1.) Et2O, -40 deg C, 3 h, 2.) Et2O, -78 deg C, 1 h 4: 1.25 h / 120 °C 5: AcOH, Zn / 24 h / Ambient temperature View Scheme
参考文献
Meltzer, P. C.; Liang, A. Y.; Brownell, A.-L.; Elmaleh, D. R.; Madras, B. K.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 855 - 862
反应条件
1: Ambient temperature 2: 14 percent / diethyl ether / 1 h / -20 °C 3: 65 percent / α-chloroethyl chloroformate (ACE-Cl) / 1 h / 100 °C View Scheme
参考文献
Meltzer, P. C.; Liang, A. Y.; Brownell, A.-L.; Elmaleh, D. R.; Madras, B. K.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 855 - 862
反应条件
1: 0.8 N aq. HCl / Heating 2: POCl3 / 1 h / Heating 3: Ambient temperature 4: 14 percent / diethyl ether / 1 h / -20 °C 5: 65 percent / α-chloroethyl chloroformate (ACE-Cl) / 1 h / 100 °C View Scheme
参考文献
Meltzer, P. C.; Liang, A. Y.; Brownell, A.-L.; Elmaleh, D. R.; Madras, B. K.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 855 - 862
反应条件
1: 2.) trifluoroacetic acid / 1.) Et2O, -40 deg C, 3 h, 2.) Et2O, -78 deg C, 1 h 2: 1.25 h / 120 °C 3: AcOH, Zn / 24 h / Ambient temperature View Scheme
参考文献
Emond; Boazi; Duchene; Chalon; Besnard; Guilloteau; Frangin
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 9 p. 757 - 772
反应条件
1: 0.75 N aq. HCl / 3 h / Heating 2: POCl3 / Heating 3: 168 h / Ambient temperature 4: 2.) trifluoroacetic acid / 1.) Et2O, -40 deg C, 3 h, 2.) Et2O, -78 deg C, 1 h 5: 1.25 h / 120 °C 6: AcOH, Zn / 24 h / Ambient temperature View Scheme
参考文献
Emond; Boazi; Duchene; Chalon; Besnard; Guilloteau; Frangin
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 9 p. 757 - 772
反应条件
1: 168 h / Ambient temperature 2: 2.) trifluoroacetic acid / 1.) Et2O, -40 deg C, 3 h, 2.) Et2O, -78 deg C, 1 h 3: 1.25 h / 120 °C 4: AcOH, Zn / 24 h / Ambient temperature View Scheme
参考文献
Emond; Boazi; Duchene; Chalon; Besnard; Guilloteau; Frangin
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 9 p. 757 - 772
